The role of hepatocyte mitochondrial DNA in liver injury
Hepatocytes, the predominant cellular constituents of the liver, exhibit the highest mitochondrial density within the human body. Remarkably, experimental insights from the latter part of the previous century involving extracellular injection of mitochondrial DNA (mtDNA) elucidated its potential to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223014907 |
| _version_ | 1797630716431826944 |
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| author | Yunkai Xu Chenshuang Chu Ziyang Shi Jiaxiang Zhang |
| author_facet | Yunkai Xu Chenshuang Chu Ziyang Shi Jiaxiang Zhang |
| author_sort | Yunkai Xu |
| collection | DOAJ |
| description | Hepatocytes, the predominant cellular constituents of the liver, exhibit the highest mitochondrial density within the human body. Remarkably, experimental insights from the latter part of the previous century involving extracellular injection of mitochondrial DNA (mtDNA) elucidated its potential to incite autoimmune disorders. Consequently, in instances of liver injury, the substantial release of mtDNA has the potential to trigger the activation of the innate immune response, thereby inducing sustained pathogenic consequences within the organism. This article provides a comprehensive retrospective analysis of recent literature pertaining to the impact of mtDNA release on various hepatic cell populations, elucidating its role and potential mechanisms in liver injury. The findings underscore the central role of mtDNA in modulating the immune system, primarily through the orchestration of a cytokine storm, further exacerbating the occurrence of liver injury. |
| first_indexed | 2024-03-11T11:11:04Z |
| format | Article |
| id | doaj.art-f718a715bf4d4181bcb2afc5145fa338 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T11:11:04Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f718a715bf4d4181bcb2afc5145fa3382023-11-12T04:38:56ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01168115692The role of hepatocyte mitochondrial DNA in liver injuryYunkai Xu0Chenshuang Chu1Ziyang Shi2Jiaxiang Zhang3School of Public Health, Anhui Medical University, Hefei, Anhui, China; The First School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, ChinaThe First School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, ChinaThe First School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, ChinaSchool of Public Health, Anhui Medical University, Hefei, Anhui, China; Correspondence to: Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.Hepatocytes, the predominant cellular constituents of the liver, exhibit the highest mitochondrial density within the human body. Remarkably, experimental insights from the latter part of the previous century involving extracellular injection of mitochondrial DNA (mtDNA) elucidated its potential to incite autoimmune disorders. Consequently, in instances of liver injury, the substantial release of mtDNA has the potential to trigger the activation of the innate immune response, thereby inducing sustained pathogenic consequences within the organism. This article provides a comprehensive retrospective analysis of recent literature pertaining to the impact of mtDNA release on various hepatic cell populations, elucidating its role and potential mechanisms in liver injury. The findings underscore the central role of mtDNA in modulating the immune system, primarily through the orchestration of a cytokine storm, further exacerbating the occurrence of liver injury.http://www.sciencedirect.com/science/article/pii/S0753332223014907Mitochondrial DNALiver injuryHepatocyteKupffer cellHepatic stellate cells |
| spellingShingle | Yunkai Xu Chenshuang Chu Ziyang Shi Jiaxiang Zhang The role of hepatocyte mitochondrial DNA in liver injury Biomedicine & Pharmacotherapy Mitochondrial DNA Liver injury Hepatocyte Kupffer cell Hepatic stellate cells |
| title | The role of hepatocyte mitochondrial DNA in liver injury |
| title_full | The role of hepatocyte mitochondrial DNA in liver injury |
| title_fullStr | The role of hepatocyte mitochondrial DNA in liver injury |
| title_full_unstemmed | The role of hepatocyte mitochondrial DNA in liver injury |
| title_short | The role of hepatocyte mitochondrial DNA in liver injury |
| title_sort | role of hepatocyte mitochondrial dna in liver injury |
| topic | Mitochondrial DNA Liver injury Hepatocyte Kupffer cell Hepatic stellate cells |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223014907 |
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