Evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol (PEG) form in vivo
Uncontrolled regulation of oxidative stress and reactive oxygen species (ROS) in living organisms might lead to the development of various diseases. Selenium is an element in antioxidant selenoproteins and is used in different forms as a food supplement. Selenium nanoparticles (SeNPs) could show imp...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | OpenNano |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352952022000718 |
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| author | Samer Y. Al-Qaraleh Wael A. Al-Zereini Sawsan A. Oran Ahmad Z. Al-Sarayreh Sa'ed M. Al-Dalain |
| author_facet | Samer Y. Al-Qaraleh Wael A. Al-Zereini Sawsan A. Oran Ahmad Z. Al-Sarayreh Sa'ed M. Al-Dalain |
| author_sort | Samer Y. Al-Qaraleh |
| collection | DOAJ |
| description | Uncontrolled regulation of oxidative stress and reactive oxygen species (ROS) in living organisms might lead to the development of various diseases. Selenium is an element in antioxidant selenoproteins and is used in different forms as a food supplement. Selenium nanoparticles (SeNPs) could show improved activity and less toxicity; their bioactivity, biocompatibility, and binding to targets might be augmented by phytochemicals decorating their surfaces during green synthesis using plant extracts. Herein, the study evaluated the antioxidant activity of Moringa peregrina-mediated SeNPs (MPM-SeNPs) and the PEGylated form (PEG-MPM-SeNPs) in vivo in lipopolysaccharide (LPS)-induced oxidative stress in a mice model. LPS injection caused a reduction in enzyme activity of both oxidative stress biomarkers superoxide dismutase (SOD) and catalase (CAT) with an elevation in protein carbonyl content level in blood sera and liver homogenates of treated mice. MPM-SeNPs and PEG-MPM-SeNPs significantly recovered SOD activity in both blood sera and liver homogenates, as well as enhanced the specific activity of CAT in LPS-injected mice. Moreover, they caused a reduction in the carbonyl content in blood sera. Thus, both SeNPs complexes were able to amend the oxidation-induced damage in the body and protect its organs against necrosis and dysfunction. |
| first_indexed | 2024-04-13T06:17:41Z |
| format | Article |
| id | doaj.art-f71949361f4a4cfe97f1c5e0f31883f1 |
| institution | Directory Open Access Journal |
| issn | 2352-9520 |
| language | English |
| last_indexed | 2024-04-13T06:17:41Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | OpenNano |
| spelling | doaj.art-f71949361f4a4cfe97f1c5e0f31883f12022-12-22T02:58:47ZengElsevierOpenNano2352-95202022-11-018100109Evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol (PEG) form in vivoSamer Y. Al-Qaraleh0Wael A. Al-Zereini1Sawsan A. Oran2Ahmad Z. Al-Sarayreh3Sa'ed M. Al-Dalain4Department of Cosmetology, Faculty of Allied Medical Sciences, Mutah University, Al-Karak 61710, Jordan; Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman 11942, Jordan; Corresponding author at: Department of Cosmetology, Faculty of Allied Medical Sciences, Mutah University, Al-Karak 61710, Jordan.Department of Biological Sciences, Faculty of Science, Mutah University, Al-Karak 61710, Jordan; W. Al-Zereini, Department of Biological Sciences, Faculty of Science, Mutah University, Al-Karak 61710, Jordan.Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman 11942, JordanDepartment of Biological Sciences, Faculty of Science, Mutah University, Al-Karak 61710, JordanDepartment of Pharmacology, Faculty of Medicine, Mutah University, Al-Karak 61710, JordanUncontrolled regulation of oxidative stress and reactive oxygen species (ROS) in living organisms might lead to the development of various diseases. Selenium is an element in antioxidant selenoproteins and is used in different forms as a food supplement. Selenium nanoparticles (SeNPs) could show improved activity and less toxicity; their bioactivity, biocompatibility, and binding to targets might be augmented by phytochemicals decorating their surfaces during green synthesis using plant extracts. Herein, the study evaluated the antioxidant activity of Moringa peregrina-mediated SeNPs (MPM-SeNPs) and the PEGylated form (PEG-MPM-SeNPs) in vivo in lipopolysaccharide (LPS)-induced oxidative stress in a mice model. LPS injection caused a reduction in enzyme activity of both oxidative stress biomarkers superoxide dismutase (SOD) and catalase (CAT) with an elevation in protein carbonyl content level in blood sera and liver homogenates of treated mice. MPM-SeNPs and PEG-MPM-SeNPs significantly recovered SOD activity in both blood sera and liver homogenates, as well as enhanced the specific activity of CAT in LPS-injected mice. Moreover, they caused a reduction in the carbonyl content in blood sera. Thus, both SeNPs complexes were able to amend the oxidation-induced damage in the body and protect its organs against necrosis and dysfunction.http://www.sciencedirect.com/science/article/pii/S2352952022000718Antioxidant activityLPSMice modelMoringa peregrinaPolyethylene glycolSelenium nanoparticle |
| spellingShingle | Samer Y. Al-Qaraleh Wael A. Al-Zereini Sawsan A. Oran Ahmad Z. Al-Sarayreh Sa'ed M. Al-Dalain Evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol (PEG) form in vivo OpenNano Antioxidant activity LPS Mice model Moringa peregrina Polyethylene glycol Selenium nanoparticle |
| title | Evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol (PEG) form in vivo |
| title_full | Evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol (PEG) form in vivo |
| title_fullStr | Evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol (PEG) form in vivo |
| title_full_unstemmed | Evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol (PEG) form in vivo |
| title_short | Evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol (PEG) form in vivo |
| title_sort | evaluation of the antioxidant activities of green synthesized selenium nanoparticles and their conjugated polyethylene glycol peg form in vivo |
| topic | Antioxidant activity LPS Mice model Moringa peregrina Polyethylene glycol Selenium nanoparticle |
| url | http://www.sciencedirect.com/science/article/pii/S2352952022000718 |
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