Screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatol
This work, a highly selective and sensitive sensor is described for voltammetric determination of the sotalol (SOT). The dual actions of sotalol lead to reductions in the automaticity of myocardial cells and in conduction through the atrioventricular node. Drug analysis has an extensive impact on pu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844019356099 |
| _version_ | 1828851542311043072 |
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| author | Mahmoud Roushani Zeynab Jalilian Azizollah Nezhadali |
| author_facet | Mahmoud Roushani Zeynab Jalilian Azizollah Nezhadali |
| author_sort | Mahmoud Roushani |
| collection | DOAJ |
| description | This work, a highly selective and sensitive sensor is described for voltammetric determination of the sotalol (SOT). The dual actions of sotalol lead to reductions in the automaticity of myocardial cells and in conduction through the atrioventricular node. Drug analysis has an extensive impact on public health. The molecularly imprinted sensor was constructed by modifying a screen printed carbon electrode (SPCE) with thiol graphene quantum dots (GQD-SH) and gold nanoparticles (AuNPs). Under optimal conditions the nanotools has a dynamic range that covers the 0.1–250 μM SOT concentration range, and the detection limit is 0.035 μM. This is lower than any of the previously reported methods. The MIP-sensor also exhibited excellent selectivity, good stability and adequate reproducibility for the detection of the SOT over its structural analogs. The prepared sensor was successfully applied to the measurement of SOT in various real samples including tablet and human blood serum. |
| first_indexed | 2024-12-12T23:34:49Z |
| format | Article |
| id | doaj.art-f7197a19f70e43a5b2625ac592c2fbae |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T23:34:49Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f7197a19f70e43a5b2625ac592c2fbae2022-12-22T00:07:35ZengElsevierHeliyon2405-84402019-06-0156e01984Screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatolMahmoud Roushani0Zeynab Jalilian1Azizollah Nezhadali2Department of Chemistry, Ilam University, Ilam, Iran; Corresponding author.Department of Chemistry, Payame Noor University, PO.Box19395-4697, Tehran, IranDepartment of Chemistry, Payame Noor University, PO.Box19395-4697, Tehran, IranThis work, a highly selective and sensitive sensor is described for voltammetric determination of the sotalol (SOT). The dual actions of sotalol lead to reductions in the automaticity of myocardial cells and in conduction through the atrioventricular node. Drug analysis has an extensive impact on public health. The molecularly imprinted sensor was constructed by modifying a screen printed carbon electrode (SPCE) with thiol graphene quantum dots (GQD-SH) and gold nanoparticles (AuNPs). Under optimal conditions the nanotools has a dynamic range that covers the 0.1–250 μM SOT concentration range, and the detection limit is 0.035 μM. This is lower than any of the previously reported methods. The MIP-sensor also exhibited excellent selectivity, good stability and adequate reproducibility for the detection of the SOT over its structural analogs. The prepared sensor was successfully applied to the measurement of SOT in various real samples including tablet and human blood serum.http://www.sciencedirect.com/science/article/pii/S2405844019356099Analytical chemistryElectrochemistryThiol graphene quantum dotsModified electrodeMolecularly imprinted polymerSotalol |
| spellingShingle | Mahmoud Roushani Zeynab Jalilian Azizollah Nezhadali Screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatol Heliyon Analytical chemistry Electrochemistry Thiol graphene quantum dots Modified electrode Molecularly imprinted polymer Sotalol |
| title | Screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatol |
| title_full | Screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatol |
| title_fullStr | Screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatol |
| title_full_unstemmed | Screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatol |
| title_short | Screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatol |
| title_sort | screen printed carbon electrode sensor with thiol graphene quantum dots and gold nanoparticles for voltammetric determination of solatol |
| topic | Analytical chemistry Electrochemistry Thiol graphene quantum dots Modified electrode Molecularly imprinted polymer Sotalol |
| url | http://www.sciencedirect.com/science/article/pii/S2405844019356099 |
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