Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin

Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a blood-lymphatic mixing phenotype. We investig...

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Bibliographic Details
Main Authors: Stacey A. Langan, Leyre Navarro-Núñez, Steve P. Watson, Gerard B. Nash
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:Platelets
Subjects:
clec-2
lymphangiogenesis
platelets
podoplanin
vegf
Online Access:http://dx.doi.org/10.1080/09537104.2017.1336210

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