Inhibition of MGAT2 modulates fat‐induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high‐fat diet

Inhibition of MGAT2 modulates fat‐induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high‐fat diet

Monoacylglycerol O‐acyltransferase 2 (MGAT2) is one of the key enzymes responsible for triglyceride (TG) re‐synthesis in the small intestine. We have previously demonstrated that pharmacological inhibition of MGAT2 has beneficial effects on obesity and metabolic disorders in mice. Here, we further i...

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Bibliographic Details
Main Authors: Taisuke Mochida, Kazumi Take, Toshiyuki Maki, Masanori Nakakariya, Ryutaro Adachi, Kenjiro Sato, Tomoyuki Kitazaki, Shiro Takekawa
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:FEBS Open Bio
Subjects:
diabetes
gut hormone
high‐fat diet
MGAT2
Monoacylglycerol O‐acyltransferase 2
obesity
Online Access:https://doi.org/10.1002/2211-5463.12778

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