Association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the US: a population-based cohort study
Abstract Background Chorioamnionitis (CAM) is a common risk factor for preterm births, resulting in several adverse outcomes. The association between infertility treatment and CAM is unclear. Therefore, this study examined the association between infertility treatment and CAM and described subsequen...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-023-05619-0 |
| _version_ | 1827943217647058944 |
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| author | Meng Ni Lijuan Li Qianqian Zhang Jiuru Zhao Wei Li Qianwen Shen Dongting Yao Tao Wang Baihe Li Xiya Ding Sudong Qi Zhiwei Liu |
| author_facet | Meng Ni Lijuan Li Qianqian Zhang Jiuru Zhao Wei Li Qianwen Shen Dongting Yao Tao Wang Baihe Li Xiya Ding Sudong Qi Zhiwei Liu |
| author_sort | Meng Ni |
| collection | DOAJ |
| description | Abstract Background Chorioamnionitis (CAM) is a common risk factor for preterm births, resulting in several adverse outcomes. The association between infertility treatment and CAM is unclear. Therefore, this study examined the association between infertility treatment and CAM and described subsequent neonatal outcomes. Methods This population-based cohort study used data from the National Vital Statistics System Database. We included women who had a singleton live birth from January 1, 2016 to December 31, 2018. Women-infant pairs were stratified by infertility treatment, and the main outcome was a reported diagnosis of CAM in a checkbox format: clinical CAM or maternal temperature of > 38 °C. Multivariate logistic regression was used to examine the association between infertility treatment and CAM and the effect of infertility treatment on neonatal outcomes in women diagnosed with CAM. Results The final sample comprised 10,900,495 woman-infant pairs, and 1.4% received infertility treatment. Compared with the natural conception group, women receiving infertility treatment had a significantly higher risk of CAM (adjusted odds ratio [aOR] 1.772 [95% confidence interval {CI}, 1.718–1.827]). Furthermore, newborns exposed to CAM had a higher risk of very low birth weight (VLBW) (aOR, 2.083 [95% CI, 1.664–2.606], P < .001), preterm birth (aOR, 1.497 [95% CI, 1.324–1.693]; P < .001), neonatal intensive care unit admission (aOR, 1.234 [95% CI, 1.156–1.317]; P < .001), and other adverse neonatal outcomes in the infertility treatment group compared with ones conceived naturally. Conclusions This study found that women who received infertility treatment had a higher risk of CAM. And CAM deteriorated neonatal outcomes in the infertility treatment group. |
| first_indexed | 2024-03-13T10:12:07Z |
| format | Article |
| id | doaj.art-f71deff51cf04b919961dc555e895a19 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-13T10:12:07Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-f71deff51cf04b919961dc555e895a192023-05-21T11:29:48ZengBMCBMC Pregnancy and Childbirth1471-23932023-05-0123111110.1186/s12884-023-05619-0Association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the US: a population-based cohort studyMeng Ni0Lijuan Li1Qianqian Zhang2Jiuru Zhao3Wei Li4Qianwen Shen5Dongting Yao6Tao Wang7Baihe Li8Xiya Ding9Sudong Qi10Zhiwei Liu11International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityAbstract Background Chorioamnionitis (CAM) is a common risk factor for preterm births, resulting in several adverse outcomes. The association between infertility treatment and CAM is unclear. Therefore, this study examined the association between infertility treatment and CAM and described subsequent neonatal outcomes. Methods This population-based cohort study used data from the National Vital Statistics System Database. We included women who had a singleton live birth from January 1, 2016 to December 31, 2018. Women-infant pairs were stratified by infertility treatment, and the main outcome was a reported diagnosis of CAM in a checkbox format: clinical CAM or maternal temperature of > 38 °C. Multivariate logistic regression was used to examine the association between infertility treatment and CAM and the effect of infertility treatment on neonatal outcomes in women diagnosed with CAM. Results The final sample comprised 10,900,495 woman-infant pairs, and 1.4% received infertility treatment. Compared with the natural conception group, women receiving infertility treatment had a significantly higher risk of CAM (adjusted odds ratio [aOR] 1.772 [95% confidence interval {CI}, 1.718–1.827]). Furthermore, newborns exposed to CAM had a higher risk of very low birth weight (VLBW) (aOR, 2.083 [95% CI, 1.664–2.606], P < .001), preterm birth (aOR, 1.497 [95% CI, 1.324–1.693]; P < .001), neonatal intensive care unit admission (aOR, 1.234 [95% CI, 1.156–1.317]; P < .001), and other adverse neonatal outcomes in the infertility treatment group compared with ones conceived naturally. Conclusions This study found that women who received infertility treatment had a higher risk of CAM. And CAM deteriorated neonatal outcomes in the infertility treatment group.https://doi.org/10.1186/s12884-023-05619-0Infertility treatmentChorioamnionitisNeonatal outcomesPreterm birthLow birth weight |
| spellingShingle | Meng Ni Lijuan Li Qianqian Zhang Jiuru Zhao Wei Li Qianwen Shen Dongting Yao Tao Wang Baihe Li Xiya Ding Sudong Qi Zhiwei Liu Association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the US: a population-based cohort study BMC Pregnancy and Childbirth Infertility treatment Chorioamnionitis Neonatal outcomes Preterm birth Low birth weight |
| title | Association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the US: a population-based cohort study |
| title_full | Association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the US: a population-based cohort study |
| title_fullStr | Association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the US: a population-based cohort study |
| title_full_unstemmed | Association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the US: a population-based cohort study |
| title_short | Association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the US: a population-based cohort study |
| title_sort | association of chorioamnionitis with infertility treatment and subsequent neonatal outcomes in the us a population based cohort study |
| topic | Infertility treatment Chorioamnionitis Neonatal outcomes Preterm birth Low birth weight |
| url | https://doi.org/10.1186/s12884-023-05619-0 |
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