Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia
Anorectal melanomas are exceptionally uncommon and only 30% of anorectal melanomas are amelanotic. We report here a case of an anorectal amelanotic melanoma in a female patient. An 84-year-old patient complained of anal mass for 3 months. On examination, there was a 7.0 cm mass prolapsing through th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences
2019-07-01
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| Series: | Middle East Journal of Digestive Diseases |
| Subjects: | |
| Online Access: | http://www.mejdd.org/index.php/mejdd/article/view/2066 |
| _version_ | 1818302256050601984 |
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| author | Khaled Ali Baniyaseen Muhammad Saeed Ahmed Omar Albonni Bothaina Mohammed Abdulshakour Ghida Dairi Faisal A. Al-Allaf Mohiuddin M. Taher |
| author_facet | Khaled Ali Baniyaseen Muhammad Saeed Ahmed Omar Albonni Bothaina Mohammed Abdulshakour Ghida Dairi Faisal A. Al-Allaf Mohiuddin M. Taher |
| author_sort | Khaled Ali Baniyaseen |
| collection | DOAJ |
| description | Anorectal melanomas are exceptionally uncommon and only 30% of anorectal melanomas are amelanotic. We report here a case of an anorectal amelanotic melanoma in a female patient. An 84-year-old patient complained of anal mass for 3 months. On examination, there was a 7.0 cm mass prolapsing through the anus that was pale-pink in color. Abdominal, pelvic, and chest computed tomography (CT) showed rectal wall thickening with an eccentric polypoid soft tissue density mass, and left inguinal and presacral lymph node enlargement along with a small nodule in the lower lobe of the left lung, likely representing metastatic deposit. Microscopic examination revealed a piece of skin with hyperplastic squamous epithelium with surface ulceration. The dermis and underlining tissue were showing infiltration by malignant sheets and nests of ovoid and spindle shape cells with prominent nucleolus and high mitotic s. Immuno-staining for HMB-45, S-100, and Melan-A was positive, and it was negative for P63, CK 5/6, and Pan-CK, thus confirming it as an anorectal amelanotic melanoma, and not an epithelial tumor. This is the first case of an amelanotic anorectal melanoma reported from Saudi Arabia. |
| first_indexed | 2024-12-13T05:36:01Z |
| format | Article |
| id | doaj.art-f71f787b6ef647c2a6c78eae4d42df64 |
| institution | Directory Open Access Journal |
| issn | 2008-5230 2008-5249 |
| language | English |
| last_indexed | 2024-12-13T05:36:01Z |
| publishDate | 2019-07-01 |
| publisher | Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Digestive Diseases |
| spelling | doaj.art-f71f787b6ef647c2a6c78eae4d42df642022-12-21T23:57:56ZengIranian Association of Gastroenterology and Hepatology, Shiraz University of Medical SciencesMiddle East Journal of Digestive Diseases2008-52302008-52492019-07-0111316617310.15171/mejdd.2019.144Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi ArabiaKhaled Ali Baniyaseen0Muhammad Saeed1Ahmed Omar Albonni2Bothaina Mohammed Abdulshakour3Ghida Dairi4Faisal A. Al-Allaf5Mohiuddin M. Taher6Histopathology Division, Al-Noor Specialist Hospital, Makkah, Saudi ArabiaFaculty of Medicine, Umm-Al-Qura University, Makkah, Saudi ArabiaHistopathology Division, King Fahad Central Hospital, Jazan, Saudi ArabiaDepartment of Radiology, Al-Noor Specialty Hospital, Makkah, Saudi ArabiaMedicine and Medical Sciences Research Center, Deanship of Scientific Research, Umm-Al-Qura University, Makkah, Saudi ArabiaDepartment of Medical Genetics, Umm-Al-Qura University, Saudi ArabiaScience and Technology Unit, Umm- Al-Qura University, Makkah, Saudi ArabiaAnorectal melanomas are exceptionally uncommon and only 30% of anorectal melanomas are amelanotic. We report here a case of an anorectal amelanotic melanoma in a female patient. An 84-year-old patient complained of anal mass for 3 months. On examination, there was a 7.0 cm mass prolapsing through the anus that was pale-pink in color. Abdominal, pelvic, and chest computed tomography (CT) showed rectal wall thickening with an eccentric polypoid soft tissue density mass, and left inguinal and presacral lymph node enlargement along with a small nodule in the lower lobe of the left lung, likely representing metastatic deposit. Microscopic examination revealed a piece of skin with hyperplastic squamous epithelium with surface ulceration. The dermis and underlining tissue were showing infiltration by malignant sheets and nests of ovoid and spindle shape cells with prominent nucleolus and high mitotic s. Immuno-staining for HMB-45, S-100, and Melan-A was positive, and it was negative for P63, CK 5/6, and Pan-CK, thus confirming it as an anorectal amelanotic melanoma, and not an epithelial tumor. This is the first case of an amelanotic anorectal melanoma reported from Saudi Arabia.http://www.mejdd.org/index.php/mejdd/article/view/2066Anorectal cancerAnorectal melanomaAmelanotic melanomaLung metastasis |
| spellingShingle | Khaled Ali Baniyaseen Muhammad Saeed Ahmed Omar Albonni Bothaina Mohammed Abdulshakour Ghida Dairi Faisal A. Al-Allaf Mohiuddin M. Taher Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia Middle East Journal of Digestive Diseases Anorectal cancer Anorectal melanoma Amelanotic melanoma Lung metastasis |
| title | Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia |
| title_full | Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia |
| title_fullStr | Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia |
| title_full_unstemmed | Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia |
| title_short | Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia |
| title_sort | primary anorectal amelanotic melanoma the first case report from saudi arabia |
| topic | Anorectal cancer Anorectal melanoma Amelanotic melanoma Lung metastasis |
| url | http://www.mejdd.org/index.php/mejdd/article/view/2066 |
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