Modulation of HMGB1 Release in APAP-Induced Liver Injury: A Possible Strategy of Chikusetsusaponin V Targeting NETs Formation

Modulation of HMGB1 Release in APAP-Induced Liver Injury: A Possible Strategy of Chikusetsusaponin V Targeting NETs Formation

Acetaminophen (APAP), one of the most common antipyretic analgesics, which is safe at therapeutic dose, cause acute liver injury and even death at overdose. However, the mechanism of APAP-induced inflammation in liver injury is still controversial. Therefore, effective drug intervention is urgently...

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Bibliographic Details
Main Authors: Jian Liu, Min Jiang, Quan Jin, Yan-Ling Wu, Zhen-Yu Cui, Ben-Wen Cui, Yue Shang, Zi-Ying Zhan, Yong-Ce Lin, Jing-Ya Jiao, Mei-Hua Piao, Zhi-Hong Zhang, Rong-Hui Sun, Ji-Xing Nan, Li-Hua Lian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
acetaminophen
drug-induced liver injury
HMGB1
neutrophil extracellular traps
chikusetsusaponin V
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.723881/full

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