Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trial
New approaches to treating periodontal diseases aim to balance sustaining the natural oral microbiota and modifying the host immune response. Gum Arabic (GA) is a natural polysaccharide rich in prebiotics.The aim of this study was to assess the effect of GA on clinical (Plaque Index (PI), Gingival I...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Saudi Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905222000736 |
| _version_ | 1811297285100797952 |
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| author | Arwa M. Gafar AbdelRahman M. Ramadan Nouar A. ElSaid Nazik M. Nurelhuda |
| author_facet | Arwa M. Gafar AbdelRahman M. Ramadan Nouar A. ElSaid Nazik M. Nurelhuda |
| author_sort | Arwa M. Gafar |
| collection | DOAJ |
| description | New approaches to treating periodontal diseases aim to balance sustaining the natural oral microbiota and modifying the host immune response. Gum Arabic (GA) is a natural polysaccharide rich in prebiotics.The aim of this study was to assess the effect of GA on clinical (Plaque Index (PI), Gingival Index (GI)) and immunological (Gingival Crevicular Fluid Interleukin 1 Beta (GCF IL-1 β)) parameters in patients with plaque-induced gingivitis. Materials and methods: This placebo-controlled, double-blinded randomised clinical trial was conducted at the Department of Periodontology at Khartoum Dental Teaching Hospital, Khartoum, Sudan, from July to October 2016. Patients diagnosed with plaque-induced gingivitis meeting the study eligibility criteria were enrolled. At baseline, PI, GI and GCF IL-1β were measured. Patients received full-mouth scaling and were randomly assigned to receive either GA powder (intervention group) or Microcrystalline cellulose powder (placebo group). The patients were instructed to apply the treatment twice a day throughout the study. The PI, GI and GCF IL-1β were reassessed after 30 and 60 days. Results: A total of 60 patients were enrolled (30 in each group). Compared to the placebo group, the intervention group showed a statistically significant reduction in GI scores after 30 days and improved PI scores at 30 and 60 days. Between baseline and 60 days, patients who received GA exhibited a significant reduction in GCF IL-1β levels compared to the placebo group. Conclusion: GA was found to be effective in controlling plaque and gingivitis.Clinical Trial Registration. ISRCTN registry ISRCTN14209449. |
| first_indexed | 2024-04-13T06:01:57Z |
| format | Article |
| id | doaj.art-f7201be654c246cb870115ed1b652311 |
| institution | Directory Open Access Journal |
| issn | 1013-9052 |
| language | English |
| last_indexed | 2024-04-13T06:01:57Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj.art-f7201be654c246cb870115ed1b6523112022-12-22T02:59:24ZengElsevierSaudi Dental Journal1013-90522022-09-01346494502Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trialArwa M. Gafar0AbdelRahman M. Ramadan1Nouar A. ElSaid2Nazik M. Nurelhuda3Sudan Medical Specialisation Board, Khartoum, SudanIbn Sina National College, Saudi ArabiaToronto, CanadaFaculty of Dentistry, University of Khartoum, Sudan; Corresponding author at: PO Box 102, Dental Public Health Unit, Faculty of Dentistry, University of Khartoum, Sudan.New approaches to treating periodontal diseases aim to balance sustaining the natural oral microbiota and modifying the host immune response. Gum Arabic (GA) is a natural polysaccharide rich in prebiotics.The aim of this study was to assess the effect of GA on clinical (Plaque Index (PI), Gingival Index (GI)) and immunological (Gingival Crevicular Fluid Interleukin 1 Beta (GCF IL-1 β)) parameters in patients with plaque-induced gingivitis. Materials and methods: This placebo-controlled, double-blinded randomised clinical trial was conducted at the Department of Periodontology at Khartoum Dental Teaching Hospital, Khartoum, Sudan, from July to October 2016. Patients diagnosed with plaque-induced gingivitis meeting the study eligibility criteria were enrolled. At baseline, PI, GI and GCF IL-1β were measured. Patients received full-mouth scaling and were randomly assigned to receive either GA powder (intervention group) or Microcrystalline cellulose powder (placebo group). The patients were instructed to apply the treatment twice a day throughout the study. The PI, GI and GCF IL-1β were reassessed after 30 and 60 days. Results: A total of 60 patients were enrolled (30 in each group). Compared to the placebo group, the intervention group showed a statistically significant reduction in GI scores after 30 days and improved PI scores at 30 and 60 days. Between baseline and 60 days, patients who received GA exhibited a significant reduction in GCF IL-1β levels compared to the placebo group. Conclusion: GA was found to be effective in controlling plaque and gingivitis.Clinical Trial Registration. ISRCTN registry ISRCTN14209449.http://www.sciencedirect.com/science/article/pii/S1013905222000736AntimicrobialChemical plaque controlClinical trialGingivitisGum Arabic |
| spellingShingle | Arwa M. Gafar AbdelRahman M. Ramadan Nouar A. ElSaid Nazik M. Nurelhuda Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trial Saudi Dental Journal Antimicrobial Chemical plaque control Clinical trial Gingivitis Gum Arabic |
| title | Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trial |
| title_full | Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trial |
| title_fullStr | Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trial |
| title_full_unstemmed | Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trial |
| title_short | Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trial |
| title_sort | effect of gum arabic on plaque induced gingivitis a randomised controlled trial |
| topic | Antimicrobial Chemical plaque control Clinical trial Gingivitis Gum Arabic |
| url | http://www.sciencedirect.com/science/article/pii/S1013905222000736 |
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