Zebrafish Paralogs <i>brd2a</i> and <i>brd2b</i> Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development

Zebrafish Paralogs <i>brd2a</i> and <i>brd2b</i> Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development

Brd2 belongs to the BET family of epigenetic transcriptional co-regulators that act as adaptor-scaffolds for the assembly of chromatin-modifying complexes and other factors at target gene promoters. Brd2 is a protooncogene and candidate gene for juvenile myoclonic epilepsy in humans, a homeobox gene...

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Bibliographic Details
Main Authors: Gregory L. Branigan, Kelly S. Olsen, Isabella Burda, Matthew W. Haemmerle, Jason Ho, Alexandra Venuto, Nicholas D. D’Antonio, Ian E. Briggs, Angela J. DiBenedetto
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Journal of Developmental Biology
Subjects:
gene duplication
functional antagonism
gene interaction
pronephros
peripheral blood island
spinal interneuron
Online Access:https://www.mdpi.com/2221-3759/9/4/46

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https://www.mdpi.com/2221-3759/9/4/46

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