Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART)
Aims: The main objective of this study is to determine whether exposure to Saharan dust causes airway inflammation and oxidative stress in patients with stable chronic heart failure (HF) and a left ventricular ejection fraction of less than 40%. Methods: A longitudinal study design is used, involvin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/4990 |
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| author | Alberto Domínguez-Rodríguez Pablo Avanzas Néstor Báez-Ferrer Pedro Abreu-González Sergio Rodríguez Sebastian Matos-Castro Daniel Hernández-Vaquero |
| author_facet | Alberto Domínguez-Rodríguez Pablo Avanzas Néstor Báez-Ferrer Pedro Abreu-González Sergio Rodríguez Sebastian Matos-Castro Daniel Hernández-Vaquero |
| author_sort | Alberto Domínguez-Rodríguez |
| collection | DOAJ |
| description | Aims: The main objective of this study is to determine whether exposure to Saharan dust causes airway inflammation and oxidative stress in patients with stable chronic heart failure (HF) and a left ventricular ejection fraction of less than 40%. Methods: A longitudinal study design is used, involving the inclusion of 40 patients with stable chronic HF and a left ventricular ejection fraction of less than 40%. Four sputum samplings will be taken from each patient, with one sampling taken each week over four consecutive weeks. The sputum samples will be used to analyze the degree of inflammation and oxidative stress. Air quality monitoring stations will be used to analyze the particulate matter (PM) exposure of each patient. The intrusion of desert dust will be identified using meteorological models. There will be 160 scheduled samplings in 40 patients with chronic HF. Mixed regression models will be used to assess the influence of the concentrations of PM (from the episodes of desert dust) upon the airway inflammation and oxidative stress markers. Conclusion: The results of this study will test the hypothesis that exposure to high concentrations of Saharan dust affects the normal function of the respiratory epithelium due to the imbalance between the production of free radicals and antioxidant enzymes, thus causing increased pulmonary inflammation and oxidative stress in patients with HF that in turn may facilitate decompensations of their background disease condition. |
| first_indexed | 2024-03-11T00:24:58Z |
| format | Article |
| id | doaj.art-f724fdd2cbd14e009d3e24e2fcdbaf59 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:24:58Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f724fdd2cbd14e009d3e24e2fcdbaf592023-11-18T23:07:55ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011215499010.3390/jcm12154990Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART)Alberto Domínguez-Rodríguez0Pablo Avanzas1Néstor Báez-Ferrer2Pedro Abreu-González3Sergio Rodríguez4Sebastian Matos-Castro5Daniel Hernández-Vaquero6Servicio de Cardiología, Hospital Universitario de Canarias, Ofra S/N La Cuesta, E-38410 Tenerife, SpainCIBER de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, SpainServicio de Cardiología, Hospital Universitario de Canarias, Ofra S/N La Cuesta, E-38410 Tenerife, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad de La Laguna, 38200 Tenerife, SpainInstituto de Productos Naturales y Agrobiología (IPNA), CSIC, 38206 Tenerife, SpainFacultad de Ciencias de la Salud, Universidad Europea de Canarias, 38300 Tenerife, SpainÁrea del Corazón, Hospital Universitario Central de Asturias (Oviedo), Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, SpainAims: The main objective of this study is to determine whether exposure to Saharan dust causes airway inflammation and oxidative stress in patients with stable chronic heart failure (HF) and a left ventricular ejection fraction of less than 40%. Methods: A longitudinal study design is used, involving the inclusion of 40 patients with stable chronic HF and a left ventricular ejection fraction of less than 40%. Four sputum samplings will be taken from each patient, with one sampling taken each week over four consecutive weeks. The sputum samples will be used to analyze the degree of inflammation and oxidative stress. Air quality monitoring stations will be used to analyze the particulate matter (PM) exposure of each patient. The intrusion of desert dust will be identified using meteorological models. There will be 160 scheduled samplings in 40 patients with chronic HF. Mixed regression models will be used to assess the influence of the concentrations of PM (from the episodes of desert dust) upon the airway inflammation and oxidative stress markers. Conclusion: The results of this study will test the hypothesis that exposure to high concentrations of Saharan dust affects the normal function of the respiratory epithelium due to the imbalance between the production of free radicals and antioxidant enzymes, thus causing increased pulmonary inflammation and oxidative stress in patients with HF that in turn may facilitate decompensations of their background disease condition.https://www.mdpi.com/2077-0383/12/15/4990air pollutiondesert dustchronic heart failureairway inflammationoxidative stressdesign study |
| spellingShingle | Alberto Domínguez-Rodríguez Pablo Avanzas Néstor Báez-Ferrer Pedro Abreu-González Sergio Rodríguez Sebastian Matos-Castro Daniel Hernández-Vaquero Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART) Journal of Clinical Medicine air pollution desert dust chronic heart failure airway inflammation oxidative stress design study |
| title | Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART) |
| title_full | Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART) |
| title_fullStr | Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART) |
| title_full_unstemmed | Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART) |
| title_short | Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART) |
| title_sort | rationale and design of the impact of air pollution due to desert dust in patients with heart failure desert heart |
| topic | air pollution desert dust chronic heart failure airway inflammation oxidative stress design study |
| url | https://www.mdpi.com/2077-0383/12/15/4990 |
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