Comparison of biventricular myocardial strain according to treatment regimens in patients discharged after COVID-19 recovery
Purpose: The effects of different COVID-19 therapeutic strategies on cardiac function are uncertain. Therefore, this study aimed to evaluate the effects of different medical treatments on biventricular function in patients who had recovered from COVID-19. Materials and Methods: Speckle-tracking echo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cukurova University
2022-09-01
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| Series: | Cukurova Medical Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/2331014 |
| _version_ | 1797907954495651840 |
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| author | Alpay Medetalibeyoğlu Ekrem Bilal Karaayvaz Yunus Çatma Huzeyfe Arıcı Derya Baykız Mustafa Altınkaynak Pelin Karaca Özer Elif Ayduk Govdelı |
| author_facet | Alpay Medetalibeyoğlu Ekrem Bilal Karaayvaz Yunus Çatma Huzeyfe Arıcı Derya Baykız Mustafa Altınkaynak Pelin Karaca Özer Elif Ayduk Govdelı |
| author_sort | Alpay Medetalibeyoğlu |
| collection | DOAJ |
| description | Purpose: The effects of different COVID-19 therapeutic strategies on cardiac function are uncertain. Therefore, this study aimed to evaluate the effects of different medical treatments on biventricular function in patients who had recovered from COVID-19.
Materials and Methods: Speckle-tracking echocardiography was performed to examine the biventricular myocardial function of patients at follow-up visits after recovery from COVID-19. The patients were divided into two groups based on the medication they used during the active disease: favipiravir (FAV; n = 60) or hydroxychloroquine (HCQ; n = 60). A comparison was made with risk factor–matched controls (n = 41).
Results: A total of 161 patients were included in the study. The left ventricular end-diastolic volume, end-systolic volume, end-diastolic diameter, and end-systolic diameter were higher in the HCQ and FAV groups compared to the controls, while the left ventricular ejection fraction was similar between all the groups. The right ventricular diameter was increased, and the systolic pulmonary artery pressure was higher in the HCQ and FAV groups compared to the controls. The left ventricular global longitudinal strain (-18±6.6 vs. -19.7±4.4 vs. -20.4±5, respectively), the right ventricular global longitudinal strain (-19.8±7.5 vs. -22.2±6 vs. -23.4±6.2, respectively), and the right ventricular free wall strain (-16.9±3.6 vs. -18.2±2.4 vs. -19.6±4.7, respectively) were worse in the HCQ group compared to the FAV and control groups.
Conclusion: This study found echocardiographic evidence of subclinical cardiac involvement in both the HCQ and FAV groups compared to the controls. However, HCQ treatment was associated with an increased risk of biventricular subclinical systolic dysfunction in COVID-19 survivors compared with FAV treatment. |
| first_indexed | 2024-04-10T10:44:58Z |
| format | Article |
| id | doaj.art-f7267af49f7b4ce9b4f01c6851573611 |
| institution | Directory Open Access Journal |
| issn | 2602-3040 |
| language | English |
| last_indexed | 2024-04-10T10:44:58Z |
| publishDate | 2022-09-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Cukurova Medical Journal |
| spelling | doaj.art-f7267af49f7b4ce9b4f01c68515736112023-02-15T16:20:21ZengCukurova UniversityCukurova Medical Journal2602-30402022-09-014731005101410.17826/cumj.109299848Comparison of biventricular myocardial strain according to treatment regimens in patients discharged after COVID-19 recoveryAlpay Medetalibeyoğlu0Ekrem Bilal Karaayvaz1Yunus Çatma2Huzeyfe Arıcı3Derya Baykız4Mustafa Altınkaynak5Pelin Karaca Özer6Elif Ayduk Govdelı7İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜİSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALIİSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜİSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜİSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALIİSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜİSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALIİSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALIPurpose: The effects of different COVID-19 therapeutic strategies on cardiac function are uncertain. Therefore, this study aimed to evaluate the effects of different medical treatments on biventricular function in patients who had recovered from COVID-19. Materials and Methods: Speckle-tracking echocardiography was performed to examine the biventricular myocardial function of patients at follow-up visits after recovery from COVID-19. The patients were divided into two groups based on the medication they used during the active disease: favipiravir (FAV; n = 60) or hydroxychloroquine (HCQ; n = 60). A comparison was made with risk factor–matched controls (n = 41). Results: A total of 161 patients were included in the study. The left ventricular end-diastolic volume, end-systolic volume, end-diastolic diameter, and end-systolic diameter were higher in the HCQ and FAV groups compared to the controls, while the left ventricular ejection fraction was similar between all the groups. The right ventricular diameter was increased, and the systolic pulmonary artery pressure was higher in the HCQ and FAV groups compared to the controls. The left ventricular global longitudinal strain (-18±6.6 vs. -19.7±4.4 vs. -20.4±5, respectively), the right ventricular global longitudinal strain (-19.8±7.5 vs. -22.2±6 vs. -23.4±6.2, respectively), and the right ventricular free wall strain (-16.9±3.6 vs. -18.2±2.4 vs. -19.6±4.7, respectively) were worse in the HCQ group compared to the FAV and control groups. Conclusion: This study found echocardiographic evidence of subclinical cardiac involvement in both the HCQ and FAV groups compared to the controls. However, HCQ treatment was associated with an increased risk of biventricular subclinical systolic dysfunction in COVID-19 survivors compared with FAV treatment.https://dergipark.org.tr/tr/download/article-file/2331014covid-19recoveryfavipiravirhydroxychloroquinespeckle tracking echocardiographycovid-19iyileşmefavipiravirhidroksiklorokinbenek izleme ekokardiyografi. |
| spellingShingle | Alpay Medetalibeyoğlu Ekrem Bilal Karaayvaz Yunus Çatma Huzeyfe Arıcı Derya Baykız Mustafa Altınkaynak Pelin Karaca Özer Elif Ayduk Govdelı Comparison of biventricular myocardial strain according to treatment regimens in patients discharged after COVID-19 recovery Cukurova Medical Journal covid-19 recovery favipiravir hydroxychloroquine speckle tracking echocardiography covid-19 iyileşme favipiravir hidroksiklorokin benek izleme ekokardiyografi. |
| title | Comparison of biventricular myocardial strain according to treatment regimens in patients discharged after COVID-19 recovery |
| title_full | Comparison of biventricular myocardial strain according to treatment regimens in patients discharged after COVID-19 recovery |
| title_fullStr | Comparison of biventricular myocardial strain according to treatment regimens in patients discharged after COVID-19 recovery |
| title_full_unstemmed | Comparison of biventricular myocardial strain according to treatment regimens in patients discharged after COVID-19 recovery |
| title_short | Comparison of biventricular myocardial strain according to treatment regimens in patients discharged after COVID-19 recovery |
| title_sort | comparison of biventricular myocardial strain according to treatment regimens in patients discharged after covid 19 recovery |
| topic | covid-19 recovery favipiravir hydroxychloroquine speckle tracking echocardiography covid-19 iyileşme favipiravir hidroksiklorokin benek izleme ekokardiyografi. |
| url | https://dergipark.org.tr/tr/download/article-file/2331014 |
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