Mesenchymal stromal cells donate mitochondria to articular chondrocytes exposed to mitochondrial, environmental, and mechanical stress

Mesenchymal stromal cells donate mitochondria to articular chondrocytes exposed to mitochondrial, environmental, and mechanical stress

Abstract Articular cartilage has limited healing capacity and no drugs are available that can prevent or slow the development of osteoarthritis (OA) after joint injury. Mesenchymal stromal cell (MSC)-based regenerative therapies for OA are increasingly common, but questions regarding their mechanism...

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Bibliographic Details
Main Authors: Megan Fahey, Maureen Bennett, Matthew Thomas, Kaylee Montney, Irene Vivancos-Koopman, Brenna Pugliese, Lindsay Browning, Lawrence J. Bonassar, Michelle Delco
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25844-5

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