Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma
Hepatitis E has emerged as a major transfusion-transmitted infectious risk. Two recipients of plasma from 2 lots (A and B) of pooled solvent/detergent–treated plasma were found to be infected by hepatitis E virus (HEV) that was determined to have been transmitted by the solvent/detergent–treated pla...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2020-12-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/26/12/19-1482_article |
| _version_ | 1818531725763936256 |
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| author | Pierre Gallian Sébastien Lhomme Pascal Morel Sylvie Gross Carole Mantovani Lisette Hauser Xavier Tinard Elodie Pouchol Rachid Djoudi Azzedine Assal Florence Abravanel Jacques Izopet Pierre Tiberghien |
| author_facet | Pierre Gallian Sébastien Lhomme Pascal Morel Sylvie Gross Carole Mantovani Lisette Hauser Xavier Tinard Elodie Pouchol Rachid Djoudi Azzedine Assal Florence Abravanel Jacques Izopet Pierre Tiberghien |
| author_sort | Pierre Gallian |
| collection | DOAJ |
| description | Hepatitis E has emerged as a major transfusion-transmitted infectious risk. Two recipients of plasma from 2 lots (A and B) of pooled solvent/detergent–treated plasma were found to be infected by hepatitis E virus (HEV) that was determined to have been transmitted by the solvent/detergent–treated plasma. HEV RNA viral loads were 433 IU in lot A and 55 IU in lot B. Retrospective studies found that 100% (13/13) of evaluable lot A recipients versus 18% (3/17) of evaluable lot B recipients had been infected by HEV (p<0.001), albeit not necessarily at time of transfusion. Among evaluable recipients, 86% with a transfused HEV RNA load >50,000 IU were infected, most likely by the HEV-containing solvent/detergent–treated plasma, versus only 7% with a transfused HEV RNA load <50,000 IU (p<0.001). Overall, solvent/detergent–treated plasma might harbor HEV. Such an occurrence might result in a dose-dependent risk for transfusion-transmitted hepatitis E. |
| first_indexed | 2024-12-11T17:36:12Z |
| format | Article |
| id | doaj.art-f72c671610904ac899a0d84e9c7f5a3d |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T17:36:12Z |
| publishDate | 2020-12-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-f72c671610904ac899a0d84e9c7f5a3d2022-12-22T00:56:40ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592020-12-0126122881288610.3201/eid2612.191482Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated PlasmaPierre GallianSébastien LhommePascal MorelSylvie GrossCarole MantovaniLisette HauserXavier TinardElodie PoucholRachid DjoudiAzzedine AssalFlorence AbravanelJacques IzopetPierre TiberghienHepatitis E has emerged as a major transfusion-transmitted infectious risk. Two recipients of plasma from 2 lots (A and B) of pooled solvent/detergent–treated plasma were found to be infected by hepatitis E virus (HEV) that was determined to have been transmitted by the solvent/detergent–treated plasma. HEV RNA viral loads were 433 IU in lot A and 55 IU in lot B. Retrospective studies found that 100% (13/13) of evaluable lot A recipients versus 18% (3/17) of evaluable lot B recipients had been infected by HEV (p<0.001), albeit not necessarily at time of transfusion. Among evaluable recipients, 86% with a transfused HEV RNA load >50,000 IU were infected, most likely by the HEV-containing solvent/detergent–treated plasma, versus only 7% with a transfused HEV RNA load <50,000 IU (p<0.001). Overall, solvent/detergent–treated plasma might harbor HEV. Such an occurrence might result in a dose-dependent risk for transfusion-transmitted hepatitis E.https://wwwnc.cdc.gov/eid/article/26/12/19-1482_articlehepatitis E virusHEVvirusestransmissionsolvent/detergent–treated plasmaplasma |
| spellingShingle | Pierre Gallian Sébastien Lhomme Pascal Morel Sylvie Gross Carole Mantovani Lisette Hauser Xavier Tinard Elodie Pouchol Rachid Djoudi Azzedine Assal Florence Abravanel Jacques Izopet Pierre Tiberghien Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma Emerging Infectious Diseases hepatitis E virus HEV viruses transmission solvent/detergent–treated plasma plasma |
| title | Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma |
| title_full | Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma |
| title_fullStr | Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma |
| title_full_unstemmed | Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma |
| title_short | Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma |
| title_sort | risk for hepatitis e virus transmission by solvent detergent treated plasma |
| topic | hepatitis E virus HEV viruses transmission solvent/detergent–treated plasma plasma |
| url | https://wwwnc.cdc.gov/eid/article/26/12/19-1482_article |
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