Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy
Abstract Background Cholangitis may affect liver failure of biliary atresia (BA) patients after Kasai portoenterostomy (KP). We examined whether the number of cholangitis episodes could be a prognostic marker for liver transplant (LT) in children with BA after Kasai portoenterostomy (KP). Methods Da...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12887-018-1074-2 |
| _version_ | 1819103134966874112 |
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| author | Szu-Ying Chen Chieh-Chung Lin Yu-Tse Tsan Wei-Cheng Chan Jiaan-Der Wang Yi-Jung Chou Ching-Heng Lin |
| author_facet | Szu-Ying Chen Chieh-Chung Lin Yu-Tse Tsan Wei-Cheng Chan Jiaan-Der Wang Yi-Jung Chou Ching-Heng Lin |
| author_sort | Szu-Ying Chen |
| collection | DOAJ |
| description | Abstract Background Cholangitis may affect liver failure of biliary atresia (BA) patients after Kasai portoenterostomy (KP). We examined whether the number of cholangitis episodes could be a prognostic marker for liver transplant (LT) in children with BA after Kasai portoenterostomy (KP). Methods Data for BA patients born after 1998 and undergoing KP were obtained from National Health Insurance Research Database (NHIRD), Taiwan. Patients were followed up until the end of 2011. Incidence and the number of cholangitis episodes were recorded and compared between patients based on LT status. Results Ninety-six (26.8%) of the 366 BA patients underwent LT. More patients who underwent KP at < 60 days of age survived with their native liver (P = 0.007). The mean age at first cholangitis was 0.9 years and 0.8 years in the LT and non-LT groups, respectively (P = 0.868). The cumulative incidence of cholangitis within 2 years after KP did not differ between the groups (hazard ratio 1.2; 95% CI 0.9–1.6). However, the total number of cholangitis episodes was higher in the LT group within 2 years after KP (P < 0.001). Conclusions Cholangitis occurrence was not related to LT in the first 2 years after KP in BA patients, but the number of cholangitis episodes could be a prognostic marker for future LT. |
| first_indexed | 2024-12-22T01:45:38Z |
| format | Article |
| id | doaj.art-f72cd2fb2a3d41efa71fa1a830ea029b |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-22T01:45:38Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-f72cd2fb2a3d41efa71fa1a830ea029b2022-12-21T18:43:06ZengBMCBMC Pediatrics1471-24312018-04-011811710.1186/s12887-018-1074-2Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomySzu-Ying Chen0Chieh-Chung Lin1Yu-Tse Tsan2Wei-Cheng Chan3Jiaan-Der Wang4Yi-Jung Chou5Ching-Heng Lin6Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Taichung Veterans General HospitalDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Taichung Veterans General HospitalDepartment of Emergency Medicine, Taichung Veterans General HospitalDepartment of Emergency Medicine, Taichung Veterans General HospitalDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Taichung Veterans General HospitalInstitute of Public Health, China Medical UniversityDepartment of Medical Research, Taichung Veterans General HospitalAbstract Background Cholangitis may affect liver failure of biliary atresia (BA) patients after Kasai portoenterostomy (KP). We examined whether the number of cholangitis episodes could be a prognostic marker for liver transplant (LT) in children with BA after Kasai portoenterostomy (KP). Methods Data for BA patients born after 1998 and undergoing KP were obtained from National Health Insurance Research Database (NHIRD), Taiwan. Patients were followed up until the end of 2011. Incidence and the number of cholangitis episodes were recorded and compared between patients based on LT status. Results Ninety-six (26.8%) of the 366 BA patients underwent LT. More patients who underwent KP at < 60 days of age survived with their native liver (P = 0.007). The mean age at first cholangitis was 0.9 years and 0.8 years in the LT and non-LT groups, respectively (P = 0.868). The cumulative incidence of cholangitis within 2 years after KP did not differ between the groups (hazard ratio 1.2; 95% CI 0.9–1.6). However, the total number of cholangitis episodes was higher in the LT group within 2 years after KP (P < 0.001). Conclusions Cholangitis occurrence was not related to LT in the first 2 years after KP in BA patients, but the number of cholangitis episodes could be a prognostic marker for future LT.http://link.springer.com/article/10.1186/s12887-018-1074-2Biliary atresiaCholangitisLiver transplantation |
| spellingShingle | Szu-Ying Chen Chieh-Chung Lin Yu-Tse Tsan Wei-Cheng Chan Jiaan-Der Wang Yi-Jung Chou Ching-Heng Lin Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy BMC Pediatrics Biliary atresia Cholangitis Liver transplantation |
| title | Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy |
| title_full | Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy |
| title_fullStr | Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy |
| title_full_unstemmed | Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy |
| title_short | Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy |
| title_sort | number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after kasai portoenterostomy |
| topic | Biliary atresia Cholangitis Liver transplantation |
| url | http://link.springer.com/article/10.1186/s12887-018-1074-2 |
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