Development of Beta-Amyloid-Specific CAR-Tregs for the Treatment of Alzheimer’s Disease

Development of Beta-Amyloid-Specific CAR-Tregs for the Treatment of Alzheimer’s Disease

Background: Alzheimer’s disease (AD) is a neurodegenerative disease that remains uncured. Its pathogenesis is characterized by the formation of β-amyloid (Aβ) plaques. The use of antigen-specific regulatory T cells (Tregs) through adoptive transfer has shown promise for the treatment of many inflamm...

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Bibliographic Details
Main Authors: Valerie Saetzler, Tobias Riet, Andrea Schienke, Pierre Henschel, Kiara Freitag, Alexander Haake, Frank L. Heppner, Laura Elisa Buitrago-Molina, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
chimeric antigen receptor
Alzheimer’s disease
beta-amyloid
regulatory T cells
single-chain fragment
Online Access:https://www.mdpi.com/2073-4409/12/16/2115

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