Ligand-displaying Escherichia coli cells and minicells for programmable delivery of toxic payloads via type IV secretion systems

Ligand-displaying Escherichia coli cells and minicells for programmable delivery of toxic payloads via type IV secretion systems

ABSTRACT Bacterial type IV secretion systems (T4SSs) are highly versatile macromolecular translocators and offer great potential for deployment as delivery systems for therapeutic intervention. One major T4SS subfamily, the conjugation machines, are well-adapted for delivery of DNA cargoes of intere...

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Bibliographic Details
Main Authors: Yang Grace Li, Kouhei Kishida, Natsumi Ogawa-Kishida, Peter J. Christie
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
conjugation
type IV secretion
CRISPR/Cas9
minicells
nanobodies
antimicrobials
Online Access:https://journals.asm.org/doi/10.1128/mbio.02143-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02143-23

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