Prospective application of poloxamer 188 in plastic surgery: A comprehensive review
An increasing number of researchers have demonstrated that poloxamer 188 (P188) can be used as a pharmaceutical excipient for clinical applications. Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery. In this review, we summarize...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2022-03-01
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| Series: | Chinese Journal of Plastic and Reconstructive Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2096691122000012 |
| _version_ | 1828116003401236480 |
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| author | Yujia Shang Shiou Zhu Fangfei Nie Yonghuan Zhen Pengbing Ding Dong Li Hua Li Yang An |
| author_facet | Yujia Shang Shiou Zhu Fangfei Nie Yonghuan Zhen Pengbing Ding Dong Li Hua Li Yang An |
| author_sort | Yujia Shang |
| collection | DOAJ |
| description | An increasing number of researchers have demonstrated that poloxamer 188 (P188) can be used as a pharmaceutical excipient for clinical applications. Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery. In this review, we summarize the positive roles of P188 in autologous fat grafting, wound healing, and cartilage transplantation. These roles include improving the survival rate of fat grafts and chondrocytes, stimulating the metabolic activity of adipocytes, promoting wound healing, and contributing to cartilage formation. Although further research is still needed, it is clear that P188 has great potential and application value in the field of plastic surgery. |
| first_indexed | 2024-04-11T12:50:15Z |
| format | Article |
| id | doaj.art-f730ab06ee264ae49f3b88df71818174 |
| institution | Directory Open Access Journal |
| issn | 2096-6911 |
| language | English |
| last_indexed | 2024-04-11T12:50:15Z |
| publishDate | 2022-03-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Chinese Journal of Plastic and Reconstructive Surgery |
| spelling | doaj.art-f730ab06ee264ae49f3b88df718181742022-12-22T04:23:14ZengKeAi Communications Co. Ltd.Chinese Journal of Plastic and Reconstructive Surgery2096-69112022-03-01413137Prospective application of poloxamer 188 in plastic surgery: A comprehensive reviewYujia Shang0Shiou Zhu1Fangfei Nie2Yonghuan Zhen3Pengbing Ding4Dong Li5Hua Li6Yang An7Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China; Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, ChinaDepartment of Plastic Surgery, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Plastic Surgery, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Plastic Surgery, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China; Corresponding authors. Department of Plastic Surgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing 100191, China.Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding author. Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenhe District, Shenyang 110016, Liaoning, China.Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China; Corresponding authors. Department of Plastic Surgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing 100191, China.An increasing number of researchers have demonstrated that poloxamer 188 (P188) can be used as a pharmaceutical excipient for clinical applications. Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery. In this review, we summarize the positive roles of P188 in autologous fat grafting, wound healing, and cartilage transplantation. These roles include improving the survival rate of fat grafts and chondrocytes, stimulating the metabolic activity of adipocytes, promoting wound healing, and contributing to cartilage formation. Although further research is still needed, it is clear that P188 has great potential and application value in the field of plastic surgery.http://www.sciencedirect.com/science/article/pii/S2096691122000012Poloxamer 188Plastic surgeryAutologous fat graftingWound healingCartilage transplantation |
| spellingShingle | Yujia Shang Shiou Zhu Fangfei Nie Yonghuan Zhen Pengbing Ding Dong Li Hua Li Yang An Prospective application of poloxamer 188 in plastic surgery: A comprehensive review Chinese Journal of Plastic and Reconstructive Surgery Poloxamer 188 Plastic surgery Autologous fat grafting Wound healing Cartilage transplantation |
| title | Prospective application of poloxamer 188 in plastic surgery: A comprehensive review |
| title_full | Prospective application of poloxamer 188 in plastic surgery: A comprehensive review |
| title_fullStr | Prospective application of poloxamer 188 in plastic surgery: A comprehensive review |
| title_full_unstemmed | Prospective application of poloxamer 188 in plastic surgery: A comprehensive review |
| title_short | Prospective application of poloxamer 188 in plastic surgery: A comprehensive review |
| title_sort | prospective application of poloxamer 188 in plastic surgery a comprehensive review |
| topic | Poloxamer 188 Plastic surgery Autologous fat grafting Wound healing Cartilage transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S2096691122000012 |
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