Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors
Vasculogenic mimicry (VM) is a mechanism whereby cancer cells form microvascular structures similar to three-dimensional channels to provide nutrients and oxygen to tumors. Unlike angiogenesis, VM is characterized by the development of new patterned three-dimensional vascular-like structures indepen...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01419/full |
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| author | Olga N. Hernández de la Cruz José Sullivan López-González Raúl García-Vázquez Yarely M. Salinas-Vera Marcos A. Muñiz-Lino Dolores Aguilar-Cazares César López-Camarillo Ángeles Carlos-Reyes |
| author_facet | Olga N. Hernández de la Cruz José Sullivan López-González Raúl García-Vázquez Yarely M. Salinas-Vera Marcos A. Muñiz-Lino Dolores Aguilar-Cazares César López-Camarillo Ángeles Carlos-Reyes |
| author_sort | Olga N. Hernández de la Cruz |
| collection | DOAJ |
| description | Vasculogenic mimicry (VM) is a mechanism whereby cancer cells form microvascular structures similar to three-dimensional channels to provide nutrients and oxygen to tumors. Unlike angiogenesis, VM is characterized by the development of new patterned three-dimensional vascular-like structures independent of endothelial cells. This phenomenon has been observed in many types of highly aggressive solid tumors. The presence of VM has also been associated with increased resistance to chemotherapy, low survival, and poor prognosis. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are non-coding RNAs that regulate gene expression at the post-transcriptional level through different pathways. In recent years, these tiny RNAs have been shown to be expressed aberrantly in different human malignancies, thus contributing to the hallmarks of cancer. In this context, miRNAs and lncRNAs can be excellent biomarkers for diagnosis, prognosis, and the prediction of response to therapy. In this review, we discuss the role that the tumor microenvironment and the epithelial-mesenchymal transition have in VM. We include an overview of the mechanisms of VM with examples of diverse types of tumors. Finally, we describe the regulation networks of lncRNAs-miRNAs and their clinical impact with the VM. Knowing the key genes that regulate and promote the development of VM in tumors with invasive, aggressive, and therapy-resistant phenotypes will facilitate the discovery of novel biomarker therapeutics against cancer as well as tools in the diagnosis and prognosis of patients. |
| first_indexed | 2024-12-11T01:03:20Z |
| format | Article |
| id | doaj.art-f731450ae3df4f04807b213906b1b52c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T01:03:20Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f731450ae3df4f04807b213906b1b52c2022-12-22T01:26:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-01-01910.3389/fonc.2019.01419490756Regulation Networks Driving Vasculogenic Mimicry in Solid TumorsOlga N. Hernández de la Cruz0José Sullivan López-González1Raúl García-Vázquez2Yarely M. Salinas-Vera3Marcos A. Muñiz-Lino4Dolores Aguilar-Cazares5César López-Camarillo6Ángeles Carlos-Reyes7Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico, MexicoLaboratorio de Cáncer de Pulmón, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico, MexicoPosgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico, MexicoPosgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico, MexicoLaboratorio de Patología y Medicina Bucal, Universidad Autónoma Metropolitana Unidad Xochimilco, Mexico, MexicoLaboratorio de Cáncer de Pulmón, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico, MexicoPosgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico, MexicoLaboratorio de Cáncer de Pulmón, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico, MexicoVasculogenic mimicry (VM) is a mechanism whereby cancer cells form microvascular structures similar to three-dimensional channels to provide nutrients and oxygen to tumors. Unlike angiogenesis, VM is characterized by the development of new patterned three-dimensional vascular-like structures independent of endothelial cells. This phenomenon has been observed in many types of highly aggressive solid tumors. The presence of VM has also been associated with increased resistance to chemotherapy, low survival, and poor prognosis. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are non-coding RNAs that regulate gene expression at the post-transcriptional level through different pathways. In recent years, these tiny RNAs have been shown to be expressed aberrantly in different human malignancies, thus contributing to the hallmarks of cancer. In this context, miRNAs and lncRNAs can be excellent biomarkers for diagnosis, prognosis, and the prediction of response to therapy. In this review, we discuss the role that the tumor microenvironment and the epithelial-mesenchymal transition have in VM. We include an overview of the mechanisms of VM with examples of diverse types of tumors. Finally, we describe the regulation networks of lncRNAs-miRNAs and their clinical impact with the VM. Knowing the key genes that regulate and promote the development of VM in tumors with invasive, aggressive, and therapy-resistant phenotypes will facilitate the discovery of novel biomarker therapeutics against cancer as well as tools in the diagnosis and prognosis of patients.https://www.frontiersin.org/article/10.3389/fonc.2019.01419/fullcancervasculogenic mimicrymicroRNAslong non-coding RNAsepithelial-mesenchymal transitiontumor microenvironment |
| spellingShingle | Olga N. Hernández de la Cruz José Sullivan López-González Raúl García-Vázquez Yarely M. Salinas-Vera Marcos A. Muñiz-Lino Dolores Aguilar-Cazares César López-Camarillo Ángeles Carlos-Reyes Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors Frontiers in Oncology cancer vasculogenic mimicry microRNAs long non-coding RNAs epithelial-mesenchymal transition tumor microenvironment |
| title | Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors |
| title_full | Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors |
| title_fullStr | Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors |
| title_full_unstemmed | Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors |
| title_short | Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors |
| title_sort | regulation networks driving vasculogenic mimicry in solid tumors |
| topic | cancer vasculogenic mimicry microRNAs long non-coding RNAs epithelial-mesenchymal transition tumor microenvironment |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.01419/full |
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