An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cells
This data article describes the infectivity of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses derived from primary CD4+ T cells treated with or without IFN-α, over a period of 12 days. TF and NT viruses described in this article were derived from the same individual (one of each from 8 infan...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340920302596 |
| _version_ | 1818839685986779136 |
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| author | Manickam Ashokkumar Aanand Sonawane Balakumaran Sathiyamani Bennett Henzeler Esakialraj L Luke Elizabeth Hanna |
| author_facet | Manickam Ashokkumar Aanand Sonawane Balakumaran Sathiyamani Bennett Henzeler Esakialraj L Luke Elizabeth Hanna |
| author_sort | Manickam Ashokkumar |
| collection | DOAJ |
| description | This data article describes the infectivity of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses derived from primary CD4+ T cells treated with or without IFN-α, over a period of 12 days. TF and NT viruses described in this article were derived from the same individual (one of each from 8 infants who acquired HIV infection through mother-to-child transmission (MTCT). IFN-α resistance to both TF and NT viruses was studied by infecting TZM-bl cells and measuring luciferase expression (expressed as relative light units, RLU). Measurement of luciferase expression is extremely sensitive and allows quantification of even small changes in gene expression at the transcriptional level. Keywords: Human immunodeficiency virus, Mother-to-Child transmission, Transmitted founder viruses, Interferon alpha resistance |
| first_indexed | 2024-12-19T03:58:14Z |
| format | Article |
| id | doaj.art-f7330f0ff5a84440ba3da4c93fb54775 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-19T03:58:14Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-f7330f0ff5a84440ba3da4c93fb547752022-12-21T20:36:47ZengElsevierData in Brief2352-34092020-04-0129An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cellsManickam Ashokkumar0Aanand Sonawane1Balakumaran Sathiyamani2Bennett Henzeler Esakialraj L3Luke Elizabeth Hanna4Department of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, India; University of Madras, Chennai, India; Corresponding author.Department of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, India; University of Madras, Chennai, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, India; Corresponding author.This data article describes the infectivity of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses derived from primary CD4+ T cells treated with or without IFN-α, over a period of 12 days. TF and NT viruses described in this article were derived from the same individual (one of each from 8 infants who acquired HIV infection through mother-to-child transmission (MTCT). IFN-α resistance to both TF and NT viruses was studied by infecting TZM-bl cells and measuring luciferase expression (expressed as relative light units, RLU). Measurement of luciferase expression is extremely sensitive and allows quantification of even small changes in gene expression at the transcriptional level. Keywords: Human immunodeficiency virus, Mother-to-Child transmission, Transmitted founder viruses, Interferon alpha resistancehttp://www.sciencedirect.com/science/article/pii/S2352340920302596 |
| spellingShingle | Manickam Ashokkumar Aanand Sonawane Balakumaran Sathiyamani Bennett Henzeler Esakialraj L Luke Elizabeth Hanna An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cells Data in Brief |
| title | An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cells |
| title_full | An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cells |
| title_fullStr | An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cells |
| title_full_unstemmed | An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cells |
| title_short | An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cells |
| title_sort | in vitro dataset on infectious potential of transmitted founder tf and non tf nt hiv 1 viruses generated from interferon alpha treated primary cd4 t cells |
| url | http://www.sciencedirect.com/science/article/pii/S2352340920302596 |
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