Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling
Even with recent advances in care, heart failure remains a major cause of morbidity and mortality, which urgently needs new treatments. One of the major antecedents of heart failure is pathological ventricular remodelling, the abnormal change in the size, shape, function or composition of the cardia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/3/661 |
| _version_ | 1797472730504757248 |
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| author | Veera Ganesh Yerra Andrew Advani |
| author_facet | Veera Ganesh Yerra Andrew Advani |
| author_sort | Veera Ganesh Yerra |
| collection | DOAJ |
| description | Even with recent advances in care, heart failure remains a major cause of morbidity and mortality, which urgently needs new treatments. One of the major antecedents of heart failure is pathological ventricular remodelling, the abnormal change in the size, shape, function or composition of the cardiac ventricles in response to load or injury. Accumulating immune cell subpopulations contribute to the change in cardiac cellular composition that occurs during ventricular remodelling, and these immune cells can facilitate heart failure development. Among cardiac immune cell subpopulations, macrophages that are recognized by their transcriptional or cell-surface expression of the chemokine receptor C-C chemokine receptor type 2 (CCR2), have emerged as playing an especially important role in adverse remodelling. Here, we assimilate the literature that has been generated over the past two decades describing the pathological roles that CCR2<sup>+</sup> macrophages play in ventricular remodelling. The goal is to facilitate research and innovation efforts in heart failure therapeutics by drawing attention to the importance of studying the manner by which CCR2<sup>+</sup> macrophages mediate their deleterious effects. |
| first_indexed | 2024-03-09T20:05:22Z |
| format | Article |
| id | doaj.art-f733589450fe47079343e0fd631a88d8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:05:22Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f733589450fe47079343e0fd631a88d82023-11-24T00:33:28ZengMDPI AGBiomedicines2227-90592022-03-0110366110.3390/biomedicines10030661Role of CCR2-Positive Macrophages in Pathological Ventricular RemodellingVeera Ganesh Yerra0Andrew Advani1Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON M5B 1T8, CanadaKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON M5B 1T8, CanadaEven with recent advances in care, heart failure remains a major cause of morbidity and mortality, which urgently needs new treatments. One of the major antecedents of heart failure is pathological ventricular remodelling, the abnormal change in the size, shape, function or composition of the cardiac ventricles in response to load or injury. Accumulating immune cell subpopulations contribute to the change in cardiac cellular composition that occurs during ventricular remodelling, and these immune cells can facilitate heart failure development. Among cardiac immune cell subpopulations, macrophages that are recognized by their transcriptional or cell-surface expression of the chemokine receptor C-C chemokine receptor type 2 (CCR2), have emerged as playing an especially important role in adverse remodelling. Here, we assimilate the literature that has been generated over the past two decades describing the pathological roles that CCR2<sup>+</sup> macrophages play in ventricular remodelling. The goal is to facilitate research and innovation efforts in heart failure therapeutics by drawing attention to the importance of studying the manner by which CCR2<sup>+</sup> macrophages mediate their deleterious effects.https://www.mdpi.com/2227-9059/10/3/661inflammationheart failureventricular remodellingmacrophagemonocyteCCR2 |
| spellingShingle | Veera Ganesh Yerra Andrew Advani Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling Biomedicines inflammation heart failure ventricular remodelling macrophage monocyte CCR2 |
| title | Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling |
| title_full | Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling |
| title_fullStr | Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling |
| title_full_unstemmed | Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling |
| title_short | Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling |
| title_sort | role of ccr2 positive macrophages in pathological ventricular remodelling |
| topic | inflammation heart failure ventricular remodelling macrophage monocyte CCR2 |
| url | https://www.mdpi.com/2227-9059/10/3/661 |
| work_keys_str_mv | AT veeraganeshyerra roleofccr2positivemacrophagesinpathologicalventricularremodelling AT andrewadvani roleofccr2positivemacrophagesinpathologicalventricularremodelling |