Vascular Resection for Intrahepatic Cholangiocarcinoma: Current Considerations
Intrahepatic cholangiocarcinoma (iCCA) accounts for approximately 10% of all primary liver cancers. Surgery is the only potentially curative treatment, even in cases of macrovascular invasion. Since resection offers the only curative chance, even extended liver resection combined with complex vascul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/17/3829 |
| _version_ | 1797521277113597952 |
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| author | Ruslan Alikhanov Anna Dudareva Miguel Ángel Trigo Alejandro Serrablo |
| author_facet | Ruslan Alikhanov Anna Dudareva Miguel Ángel Trigo Alejandro Serrablo |
| author_sort | Ruslan Alikhanov |
| collection | DOAJ |
| description | Intrahepatic cholangiocarcinoma (iCCA) accounts for approximately 10% of all primary liver cancers. Surgery is the only potentially curative treatment, even in cases of macrovascular invasion. Since resection offers the only curative chance, even extended liver resection combined with complex vascular or biliary reconstruction of the surrounding organs seems justified to achieve complete tumour removal. In selected cases, the major vascular resection is the only change to try getting the cure. The best results are achieved by the referral centre with a wide experience in complex liver surgery, such as ALPPS procedure, IVC resection, and ante-situ and ex-situ resections. However, despite aggressive surgery, tumour recurrence occurs frequently and long-term oncological results are very poor. This suggests that significant progress in prognosis cannot be expected by surgery alone. Instead, multimodal treatment including neoadjuvant chemotherapy, radiotherapy, and subsequent adjuvant treatment for iCCA seem to be necessary to improve results. |
| first_indexed | 2024-03-10T08:10:18Z |
| format | Article |
| id | doaj.art-f7356b222c5841609a36dbe56d9d071c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:10:18Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f7356b222c5841609a36dbe56d9d071c2023-11-22T10:48:02ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-011017382910.3390/jcm10173829Vascular Resection for Intrahepatic Cholangiocarcinoma: Current ConsiderationsRuslan Alikhanov0Anna Dudareva1Miguel Ángel Trigo2Alejandro Serrablo3Department of Liver and Pancreatic Surgery, Department of Transplantation, Moscow Clinical Scientific Centre, 111123 Moscow, RussiaDepartment of Vascular Surgery, Moscow Clinical Scientific Centre, 111123 Moscow, RussiaDepartment of Pathology, Miguel Servet University Hospital, 50009 Zaragoza, SpainHPB Surgical Division, Miguel Servet University Hospital, 50009 Zaragoza, SpainIntrahepatic cholangiocarcinoma (iCCA) accounts for approximately 10% of all primary liver cancers. Surgery is the only potentially curative treatment, even in cases of macrovascular invasion. Since resection offers the only curative chance, even extended liver resection combined with complex vascular or biliary reconstruction of the surrounding organs seems justified to achieve complete tumour removal. In selected cases, the major vascular resection is the only change to try getting the cure. The best results are achieved by the referral centre with a wide experience in complex liver surgery, such as ALPPS procedure, IVC resection, and ante-situ and ex-situ resections. However, despite aggressive surgery, tumour recurrence occurs frequently and long-term oncological results are very poor. This suggests that significant progress in prognosis cannot be expected by surgery alone. Instead, multimodal treatment including neoadjuvant chemotherapy, radiotherapy, and subsequent adjuvant treatment for iCCA seem to be necessary to improve results.https://www.mdpi.com/2077-0383/10/17/3829cholangiocarcinomaliver resectionintrahepatic cholangiocarcinomasurvivalvascular resection |
| spellingShingle | Ruslan Alikhanov Anna Dudareva Miguel Ángel Trigo Alejandro Serrablo Vascular Resection for Intrahepatic Cholangiocarcinoma: Current Considerations Journal of Clinical Medicine cholangiocarcinoma liver resection intrahepatic cholangiocarcinoma survival vascular resection |
| title | Vascular Resection for Intrahepatic Cholangiocarcinoma: Current Considerations |
| title_full | Vascular Resection for Intrahepatic Cholangiocarcinoma: Current Considerations |
| title_fullStr | Vascular Resection for Intrahepatic Cholangiocarcinoma: Current Considerations |
| title_full_unstemmed | Vascular Resection for Intrahepatic Cholangiocarcinoma: Current Considerations |
| title_short | Vascular Resection for Intrahepatic Cholangiocarcinoma: Current Considerations |
| title_sort | vascular resection for intrahepatic cholangiocarcinoma current considerations |
| topic | cholangiocarcinoma liver resection intrahepatic cholangiocarcinoma survival vascular resection |
| url | https://www.mdpi.com/2077-0383/10/17/3829 |
| work_keys_str_mv | AT ruslanalikhanov vascularresectionforintrahepaticcholangiocarcinomacurrentconsiderations AT annadudareva vascularresectionforintrahepaticcholangiocarcinomacurrentconsiderations AT miguelangeltrigo vascularresectionforintrahepaticcholangiocarcinomacurrentconsiderations AT alejandroserrablo vascularresectionforintrahepaticcholangiocarcinomacurrentconsiderations |