Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review
Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease (DKD). Compared to the vast body of evidence from preclinical in vitro and in vivo studies, evidence from human studies is limited. In a comprehensive search of the published literature, findings from studies that...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/16/2481 |
| _version_ | 1827618037975482368 |
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| author | Nicole Flemming Laura Pernoud Josephine Forbes Linda Gallo |
| author_facet | Nicole Flemming Laura Pernoud Josephine Forbes Linda Gallo |
| author_sort | Nicole Flemming |
| collection | DOAJ |
| description | Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease (DKD). Compared to the vast body of evidence from preclinical in vitro and in vivo studies, evidence from human studies is limited. In a comprehensive search of the published literature, findings from studies that reported evidence of mitochondrial dysfunction in individuals with DKD were examined. Three electronic databases (PubMed, Embase, and Scopus) were searched in March 2022. A total of 1339 articles were identified, and 22 articles met the inclusion criteria. Compared to non-diabetic controls (NDC) and/or individuals with diabetes but without kidney disease (DC), individuals with DKD (age ~55 years; diabetes duration ~15 years) had evidence of mitochondrial dysfunction. Individuals with DKD had evidence of disrupted mitochondrial dynamics (11 of 11 articles)<i>,</i> uncoupling (2 of 2 articles), oxidative damage (8 of 8 articles), decreased mitochondrial respiratory capacity (1 of 1 article), decreased mtDNA content (5 of 6 articles), and decreased antioxidant capacity (3 of 4 articles) compared to ND and/or DC. Neither diabetes nor glycemic control explained these findings, but rather presence and severity of DKD may better reflect degree of mitochondrial dysfunction in this population. Future clinical studies should include individuals closer to diagnosis of diabetes to ascertain whether mitochondrial dysfunction is implicated in the development of, or is a consequence of, DKD. |
| first_indexed | 2024-03-09T10:00:00Z |
| format | Article |
| id | doaj.art-f735e8d4f7594a3d81e1204f8de93749 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T10:00:00Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f735e8d4f7594a3d81e1204f8de937492023-12-01T23:33:17ZengMDPI AGCells2073-44092022-08-011116248110.3390/cells11162481Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic ReviewNicole Flemming0Laura Pernoud1Josephine Forbes2Linda Gallo3School of Medicine and Dentistry, Griffith University, Birtinya 4556, AustraliaSchool of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore 4558, AustraliaMater Research Institute, The University of Queensland (MRI-UQ), Brisbane 4072, AustraliaSchool of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore 4558, AustraliaMitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease (DKD). Compared to the vast body of evidence from preclinical in vitro and in vivo studies, evidence from human studies is limited. In a comprehensive search of the published literature, findings from studies that reported evidence of mitochondrial dysfunction in individuals with DKD were examined. Three electronic databases (PubMed, Embase, and Scopus) were searched in March 2022. A total of 1339 articles were identified, and 22 articles met the inclusion criteria. Compared to non-diabetic controls (NDC) and/or individuals with diabetes but without kidney disease (DC), individuals with DKD (age ~55 years; diabetes duration ~15 years) had evidence of mitochondrial dysfunction. Individuals with DKD had evidence of disrupted mitochondrial dynamics (11 of 11 articles)<i>,</i> uncoupling (2 of 2 articles), oxidative damage (8 of 8 articles), decreased mitochondrial respiratory capacity (1 of 1 article), decreased mtDNA content (5 of 6 articles), and decreased antioxidant capacity (3 of 4 articles) compared to ND and/or DC. Neither diabetes nor glycemic control explained these findings, but rather presence and severity of DKD may better reflect degree of mitochondrial dysfunction in this population. Future clinical studies should include individuals closer to diagnosis of diabetes to ascertain whether mitochondrial dysfunction is implicated in the development of, or is a consequence of, DKD.https://www.mdpi.com/2073-4409/11/16/2481mitochondrial dysfunctionmitochondrial dynamicsmitophagymitochondrial fissionmitochondrial fusionoxidative stress |
| spellingShingle | Nicole Flemming Laura Pernoud Josephine Forbes Linda Gallo Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review Cells mitochondrial dysfunction mitochondrial dynamics mitophagy mitochondrial fission mitochondrial fusion oxidative stress |
| title | Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review |
| title_full | Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review |
| title_fullStr | Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review |
| title_full_unstemmed | Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review |
| title_short | Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review |
| title_sort | mitochondrial dysfunction in individuals with diabetic kidney disease a systematic review |
| topic | mitochondrial dysfunction mitochondrial dynamics mitophagy mitochondrial fission mitochondrial fusion oxidative stress |
| url | https://www.mdpi.com/2073-4409/11/16/2481 |
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