The effect of zinc on healing of renal damage in rats
Background: Several studies have previously been performed to promote kidney healing after injuries. Objectives: The aim of this study was to investigate the effect of zinc on renal healing after traumatic injury in rats. Materials and Methods: Forty healthy female rats were selected and one of thei...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2017-07-01
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| Series: | Journal of Nephropathology |
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| Online Access: | https://nephropathol.com/PDF/jnp-6-157.pdf |
| _version_ | 1797828016439558144 |
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| author | Mehdi Salehipour Ahmad Monabbati Mohammad Reza Ensafdaran Ali Adib Amir Hossein Babaei |
| author_facet | Mehdi Salehipour Ahmad Monabbati Mohammad Reza Ensafdaran Ali Adib Amir Hossein Babaei |
| author_sort | Mehdi Salehipour |
| collection | DOAJ |
| description | Background: Several studies have previously been performed to promote kidney healing after injuries. Objectives: The aim of this study was to investigate the effect of zinc on renal healing after traumatic injury in rats. Materials and Methods: Forty healthy female rats were selected and one of their kidneys was incised. Half of the incisions were limited only to the cortex (renal injury type I) and the other ones reached the pelvocalyceal system of the kidney (renal injury type II). All the rats in the zinc treated group (case group) received 36.3 mg zinc sulfate (contained 8.25 mg zinc) orally. After 28 days, the damaged kidneys were removed for histopathological studies. Results: In the rats with type I injury, kidney inflammation of the case group was significantly lower than that of the control group. However, the result was not significant in rats with type II injury. Tissue loss and granulation tissue formation were significantly lower in the case group than the control group in both type I and II kidney injuries. Conclusions: Overall, Zinc can contribute to better healing of the rat’s kidneys after a traumatic injury. |
| first_indexed | 2024-04-09T12:57:42Z |
| format | Article |
| id | doaj.art-f73657ce58e04cd1bd09b3166af12b35 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:42Z |
| publishDate | 2017-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-f73657ce58e04cd1bd09b3166af12b352023-05-13T11:31:23ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192017-07-016315716210.15171/jnp.2017.27JNP_20170220213047The effect of zinc on healing of renal damage in ratsMehdi Salehipour0Ahmad Monabbati1Mohammad Reza Ensafdaran2Ali Adib3Amir Hossein Babaei4Department of Urology, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Urology, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranBackground: Several studies have previously been performed to promote kidney healing after injuries. Objectives: The aim of this study was to investigate the effect of zinc on renal healing after traumatic injury in rats. Materials and Methods: Forty healthy female rats were selected and one of their kidneys was incised. Half of the incisions were limited only to the cortex (renal injury type I) and the other ones reached the pelvocalyceal system of the kidney (renal injury type II). All the rats in the zinc treated group (case group) received 36.3 mg zinc sulfate (contained 8.25 mg zinc) orally. After 28 days, the damaged kidneys were removed for histopathological studies. Results: In the rats with type I injury, kidney inflammation of the case group was significantly lower than that of the control group. However, the result was not significant in rats with type II injury. Tissue loss and granulation tissue formation were significantly lower in the case group than the control group in both type I and II kidney injuries. Conclusions: Overall, Zinc can contribute to better healing of the rat’s kidneys after a traumatic injury.https://nephropathol.com/PDF/jnp-6-157.pdfkidneytraumawound healingzinc |
| spellingShingle | Mehdi Salehipour Ahmad Monabbati Mohammad Reza Ensafdaran Ali Adib Amir Hossein Babaei The effect of zinc on healing of renal damage in rats Journal of Nephropathology kidney trauma wound healing zinc |
| title | The effect of zinc on healing of renal damage in rats |
| title_full | The effect of zinc on healing of renal damage in rats |
| title_fullStr | The effect of zinc on healing of renal damage in rats |
| title_full_unstemmed | The effect of zinc on healing of renal damage in rats |
| title_short | The effect of zinc on healing of renal damage in rats |
| title_sort | effect of zinc on healing of renal damage in rats |
| topic | kidney trauma wound healing zinc |
| url | https://nephropathol.com/PDF/jnp-6-157.pdf |
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