CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION
In this paper we thought to investigate clinical value of tissue inhibitor of metalloproteinase-1 (TIMP-1) in predicting left ventricular (LV) myocardial remodeling in patients having Q-wave myocardial infarction (Q-wave MI). We demonstrated that TIMP-1 serum level clearly corresponds to degree of p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2019-06-01
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| Series: | Атеросклероз |
| Subjects: | |
| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/131/331 |
| _version_ | 1797966012616802304 |
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| author | A. S. Vorobyev L. V. Kovalenko K. Yu. Nikolaev I. A. Urvantseva T. О. Simonyan М. I. Rudenko |
| author_facet | A. S. Vorobyev L. V. Kovalenko K. Yu. Nikolaev I. A. Urvantseva T. О. Simonyan М. I. Rudenko |
| author_sort | A. S. Vorobyev |
| collection | DOAJ |
| description | In this paper we thought to investigate clinical value of tissue inhibitor of metalloproteinase-1 (TIMP-1) in predicting left ventricular (LV) myocardial remodeling in patients having Q-wave myocardial infarction (Q-wave MI). We demonstrated that TIMP-1 serum level clearly corresponds to degree of postinfarction LV myocardial remodeling. In patients who had serum concentrations of TIMP-1 over the established cut-off value (144.0 ng/ml), the risk of post-infarction LV remodeling was 3.33 times higher than in individuals who had TIMP-1 levels lower this value. Thus, TIMP-1 is a reliable prediction biomarker of adverse left ventricular myocardial remodeling in Q-wave MI. |
| first_indexed | 2024-04-11T02:07:57Z |
| format | Article |
| id | doaj.art-f7368b1c6e5d4a43b42f04967dc16759 |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T02:07:57Z |
| publishDate | 2019-06-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-f7368b1c6e5d4a43b42f04967dc167592023-01-03T02:44:13ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2019-06-011521723https://doi.org/10.15372/ATER20190203CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTIONA. S. Vorobyev0L. V. Kovalenko1K. Yu. Nikolaev2I. A. Urvantseva3T. О. Simonyan4М. I. Rudenko5Surgut State University; District Cardiology Clinic Center of Diagnostics and Cardiovascular Surgery Russian FederationSurgut State University Russian FederationSurgut State University; Research Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS Russian FederationSurgut State University; District Cardiology Clinic Center of Diagnostics and Cardiovascular Surgery Russian FederationSurgut State University Russian FederationSurgut State University Russian FederationIn this paper we thought to investigate clinical value of tissue inhibitor of metalloproteinase-1 (TIMP-1) in predicting left ventricular (LV) myocardial remodeling in patients having Q-wave myocardial infarction (Q-wave MI). We demonstrated that TIMP-1 serum level clearly corresponds to degree of postinfarction LV myocardial remodeling. In patients who had serum concentrations of TIMP-1 over the established cut-off value (144.0 ng/ml), the risk of post-infarction LV remodeling was 3.33 times higher than in individuals who had TIMP-1 levels lower this value. Thus, TIMP-1 is a reliable prediction biomarker of adverse left ventricular myocardial remodeling in Q-wave MI.https://ateroskleroz.elpub.ru/jour/article/view/131/331myocardial infarctionmyocardial remodelingtimp-1prediction. |
| spellingShingle | A. S. Vorobyev L. V. Kovalenko K. Yu. Nikolaev I. A. Urvantseva T. О. Simonyan М. I. Rudenko CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION Атеросклероз myocardial infarction myocardial remodeling timp-1 prediction. |
| title | CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION |
| title_full | CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION |
| title_fullStr | CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION |
| title_full_unstemmed | CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION |
| title_short | CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION |
| title_sort | clinical predictive value of tissue inhibitor of metalloproteinase 1 imyocardial remodeling development in patients having q wave myocardial infarction |
| topic | myocardial infarction myocardial remodeling timp-1 prediction. |
| url | https://ateroskleroz.elpub.ru/jour/article/view/131/331 |
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