Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population
Abnormalities in lipid metabolism have been linked to the development of obesity. We used a nutrigenetic approach to establish a link between lipids and obesity in Asian Indians, who are known to have a high prevalence of central obesity and dyslipidaemia. A sample of 497 Asian Indian individuals (2...
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MDPI AG
2022-06-01
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| author | Ramatu Wuni Evelyn Adela Nathania Ashok K. Ayyappa Nagarajan Lakshmipriya Kandaswamy Ramya Rajagopal Gayathri Gunasekaran Geetha Ranjit Mohan Anjana Gunter G. C. Kuhnle Venkatesan Radha Viswanathan Mohan Vasudevan Sudha Karani Santhanakrishnan Vimaleswaran |
| author_facet | Ramatu Wuni Evelyn Adela Nathania Ashok K. Ayyappa Nagarajan Lakshmipriya Kandaswamy Ramya Rajagopal Gayathri Gunasekaran Geetha Ranjit Mohan Anjana Gunter G. C. Kuhnle Venkatesan Radha Viswanathan Mohan Vasudevan Sudha Karani Santhanakrishnan Vimaleswaran |
| author_sort | Ramatu Wuni |
| collection | DOAJ |
| description | Abnormalities in lipid metabolism have been linked to the development of obesity. We used a nutrigenetic approach to establish a link between lipids and obesity in Asian Indians, who are known to have a high prevalence of central obesity and dyslipidaemia. A sample of 497 Asian Indian individuals (260 with type 2 diabetes and 237 with normal glucose tolerance) (mean age: 44 ± 10 years) were randomly chosen from the Chennai Urban Rural Epidemiological Study (CURES). Dietary intake was assessed using a previously validated questionnaire. A genetic risk score (GRS) was constructed based on cholesteryl ester transfer protein (<i>CETP</i>) and lipoprotein lipase (<i>LPL</i>) genetic variants. There was a significant interaction between GRS and saturated fatty acid (SFA) intake on waist circumference (WC) (P<sub>interaction</sub> = 0.006). Individuals with a low SFA intake (≤23.2 g/day), despite carrying ≥2 risk alleles, had a smaller WC compared to individuals carrying <2 risk alleles (Beta = −0.01 cm; <i>p</i> = 0.03). For those individuals carrying ≥2 risk alleles, a high SFA intake (>23.2 g/day) was significantly associated with a larger WC than a low SFA intake (≤23.2 g/day) (Beta = 0.02 cm, <i>p</i> = 0.02). There were no significant interactions between GRS and other dietary factors on any of the measured outcomes. We conclude that a diet low in SFA might help reduce the genetic risk of central obesity confirmed by <i>CETP</i> and <i>LPL</i> genetic variants. Conversely, a high SFA diet increases the genetic risk of central obesity in Asian Indians. |
| first_indexed | 2024-03-09T12:41:25Z |
| format | Article |
| id | doaj.art-f73745af152c46c9b7cb3f21411a3474 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T12:41:25Z |
| publishDate | 2022-06-01 |
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| series | Nutrients |
| spelling | doaj.art-f73745af152c46c9b7cb3f21411a34742023-11-30T22:18:20ZengMDPI AGNutrients2072-66432022-06-011413271310.3390/nu14132713Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian PopulationRamatu Wuni0Evelyn Adela Nathania1Ashok K. Ayyappa2Nagarajan Lakshmipriya3Kandaswamy Ramya4Rajagopal Gayathri5Gunasekaran Geetha6Ranjit Mohan Anjana7Gunter G. C. Kuhnle8Venkatesan Radha9Viswanathan Mohan10Vasudevan Sudha11Karani Santhanakrishnan Vimaleswaran12Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UKIndonesia International Institute for Life Sciences, JI. Pulomas Barat Kav. 88, Jakarta Timur 13210, IndonesiaDepartment of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, IndiaDepartment of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, IndiaDepartment of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, IndiaDepartment of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, IndiaDepartment of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, IndiaDepartment of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, IndiaHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UKDepartment of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, IndiaDepartment of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, IndiaDepartment of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, IndiaHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UKAbnormalities in lipid metabolism have been linked to the development of obesity. We used a nutrigenetic approach to establish a link between lipids and obesity in Asian Indians, who are known to have a high prevalence of central obesity and dyslipidaemia. A sample of 497 Asian Indian individuals (260 with type 2 diabetes and 237 with normal glucose tolerance) (mean age: 44 ± 10 years) were randomly chosen from the Chennai Urban Rural Epidemiological Study (CURES). Dietary intake was assessed using a previously validated questionnaire. A genetic risk score (GRS) was constructed based on cholesteryl ester transfer protein (<i>CETP</i>) and lipoprotein lipase (<i>LPL</i>) genetic variants. There was a significant interaction between GRS and saturated fatty acid (SFA) intake on waist circumference (WC) (P<sub>interaction</sub> = 0.006). Individuals with a low SFA intake (≤23.2 g/day), despite carrying ≥2 risk alleles, had a smaller WC compared to individuals carrying <2 risk alleles (Beta = −0.01 cm; <i>p</i> = 0.03). For those individuals carrying ≥2 risk alleles, a high SFA intake (>23.2 g/day) was significantly associated with a larger WC than a low SFA intake (≤23.2 g/day) (Beta = 0.02 cm, <i>p</i> = 0.02). There were no significant interactions between GRS and other dietary factors on any of the measured outcomes. We conclude that a diet low in SFA might help reduce the genetic risk of central obesity confirmed by <i>CETP</i> and <i>LPL</i> genetic variants. Conversely, a high SFA diet increases the genetic risk of central obesity in Asian Indians.https://www.mdpi.com/2072-6643/14/13/2713genetic risk scoreAsian Indianslipidscentral obesityfat intakegene-diet interaction |
| spellingShingle | Ramatu Wuni Evelyn Adela Nathania Ashok K. Ayyappa Nagarajan Lakshmipriya Kandaswamy Ramya Rajagopal Gayathri Gunasekaran Geetha Ranjit Mohan Anjana Gunter G. C. Kuhnle Venkatesan Radha Viswanathan Mohan Vasudevan Sudha Karani Santhanakrishnan Vimaleswaran Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population Nutrients genetic risk score Asian Indians lipids central obesity fat intake gene-diet interaction |
| title | Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population |
| title_full | Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population |
| title_fullStr | Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population |
| title_full_unstemmed | Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population |
| title_short | Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population |
| title_sort | impact of lipid genetic risk score and saturated fatty acid intake on central obesity in an asian indian population |
| topic | genetic risk score Asian Indians lipids central obesity fat intake gene-diet interaction |
| url | https://www.mdpi.com/2072-6643/14/13/2713 |
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