Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair

Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair

Summary: Cancer cells maintain telomeres by upregulating telomerase or alternative lengthening of telomeres (ALT) via homology-directed repair at telomeric DNA breaks. 8-Oxoguanine (8oxoG) is a highly prevalent endogenous DNA lesion in telomeric sequences, altering telomere structure and telomerase...

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Bibliographic Details
Main Authors: Sanjana A. Thosar, Ryan P. Barnes, Ariana Detwiler, Ragini Bhargava, Anne Wondisford, Roderick J. O’Sullivan, Patricia L. Opresko
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723016674

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