Ablation of TRPV1-positive nerves exacerbates salt-induced hypertension and tissue injury in rats after renal ischemia-reperfusion via infiltration of macrophages

Ablation of TRPV1-positive nerves exacerbates salt-induced hypertension and tissue injury in rats after renal ischemia-reperfusion via infiltration of macrophages

Background: High-salt intake after renal ischemia/reperfusion (I/R) injury leads to hypertension and further renal injury, but the mechanisms are largely unknown. This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-i...

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Bibliographic Details
Main Authors: Shuang-Quan Yu, Shuangtao Ma, Donna H. Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-04-01
Series:Clinical and Experimental Hypertension
Subjects:
trpv1
hypertension
ischemia/reperfusion
salt intake
macrophage
Online Access:http://dx.doi.org/10.1080/10641963.2020.1860078

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