Cytoophidia Maintain the Integrity of <i>Drosophila</i> Follicle Epithelium
CTP synthase (CTPS) forms a filamentous structure termed the cytoophidium in all three domains of life. The female reproductive system of <i>Drosophila</i> is an excellent model for studying the physiological function of cytoophidia. Here, we use <i>CTPS<sup>H355A</sup>...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/23/15282 |
| Summary: | CTP synthase (CTPS) forms a filamentous structure termed the cytoophidium in all three domains of life. The female reproductive system of <i>Drosophila</i> is an excellent model for studying the physiological function of cytoophidia. Here, we use <i>CTPS<sup>H355A</sup></i>, a point mutation that destroys the cytoophidium-forming ability of CTPS, to explore the in vivo function of cytoophidia. In <i>CTPS<sup>H355A</sup></i> egg chambers, we observe the ingression and increased heterogeneity of follicle cells. In addition, we find that the cytoophidium-forming ability of CTPS, rather than the protein level, is the cause of the defects observed in <i>CTPS<sup>H355A</sup></i> mutants. To sum up, our data indicate that cytoophidia play an important role in maintaining the integrity of follicle epithelium. |
|---|---|
| ISSN: | 1661-6596 1422-0067 |