Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel
Summary: Current trends in wound care research focus on creating dressings for diverse wound types, aiming to effectively control the wound healing process. We proposed a wound dressing composed of oxidized hyaluronic acid and amine gelatin with embedded lysine-modified gelatin nanoparticles (HGel-G...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224000816 |
| _version_ | 1797345962396483584 |
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| author | Sureerat Khunmanee Anseo Choi Il Young Ahn Woo Ju Kim Tae Hui Bae Shin Hyuk Kang Hansoo Park |
| author_facet | Sureerat Khunmanee Anseo Choi Il Young Ahn Woo Ju Kim Tae Hui Bae Shin Hyuk Kang Hansoo Park |
| author_sort | Sureerat Khunmanee |
| collection | DOAJ |
| description | Summary: Current trends in wound care research focus on creating dressings for diverse wound types, aiming to effectively control the wound healing process. We proposed a wound dressing composed of oxidized hyaluronic acid and amine gelatin with embedded lysine-modified gelatin nanoparticles (HGel-GNPs-lysine). This dressing improves mechanical properties and reduces degradation rates. The storage modulus for HGel-GNPs-lysine was 3,800 Pa, exceeding that of HGel (1,750 Pa). The positively charged surface of GNPs-lysine effectively eliminated Escherichia coli and Staphylococcus aureus. In a diabetic mice model (C57BL/6), HGel-GNPs-lysine immobilized with basic-fibroblast growth factor promoted granulation tissue thickness and collagen density. Gene expression analysis indicated that HGel-GNPs-lysine reduced inflammation and enhanced angiogenesis. This study highlights that HGel-GNPs-lysine could offer alternative treatment strategies for regulating the inflammatory response at the injury site in wound dressing applications. |
| first_indexed | 2024-03-08T11:26:21Z |
| format | Article |
| id | doaj.art-f73a8078fffe4914b38a1d1e52cf8f2b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T11:26:21Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-f73a8078fffe4914b38a1d1e52cf8f2b2024-01-26T05:34:22ZengElsevieriScience2589-00422024-02-01272108860Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogelSureerat Khunmanee0Anseo Choi1Il Young Ahn2Woo Ju Kim3Tae Hui Bae4Shin Hyuk Kang5Hansoo Park6Department of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, South KoreaDepartment of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, South KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu 06973, South KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Gwangmyeong Hospital, Deokan-ro, Gwangmyeong-si, Gyeonggi-do 14353, South KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Gwangmyeong Hospital, Deokan-ro, Gwangmyeong-si, Gyeonggi-do 14353, South KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu 06973, South Korea; Corresponding authorDepartment of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, South Korea; Corresponding authorSummary: Current trends in wound care research focus on creating dressings for diverse wound types, aiming to effectively control the wound healing process. We proposed a wound dressing composed of oxidized hyaluronic acid and amine gelatin with embedded lysine-modified gelatin nanoparticles (HGel-GNPs-lysine). This dressing improves mechanical properties and reduces degradation rates. The storage modulus for HGel-GNPs-lysine was 3,800 Pa, exceeding that of HGel (1,750 Pa). The positively charged surface of GNPs-lysine effectively eliminated Escherichia coli and Staphylococcus aureus. In a diabetic mice model (C57BL/6), HGel-GNPs-lysine immobilized with basic-fibroblast growth factor promoted granulation tissue thickness and collagen density. Gene expression analysis indicated that HGel-GNPs-lysine reduced inflammation and enhanced angiogenesis. This study highlights that HGel-GNPs-lysine could offer alternative treatment strategies for regulating the inflammatory response at the injury site in wound dressing applications.http://www.sciencedirect.com/science/article/pii/S2589004224000816BioengineeringBiotechnologyMaterials scienceBiomaterials |
| spellingShingle | Sureerat Khunmanee Anseo Choi Il Young Ahn Woo Ju Kim Tae Hui Bae Shin Hyuk Kang Hansoo Park Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel iScience Bioengineering Biotechnology Materials science Biomaterials |
| title | Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel |
| title_full | Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel |
| title_fullStr | Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel |
| title_full_unstemmed | Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel |
| title_short | Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel |
| title_sort | effective wound healing on diabetic mice by adhesive antibacterial gnps lysine composited hydrogel |
| topic | Bioengineering Biotechnology Materials science Biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224000816 |
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