Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study
Background Acne is the most prevalent skin disease in the world and antibiotics as its standard treatments have limited and also adverse effects. Cedar (Ziziphus spina-christi) has medicinal properties like antibacterial activity and is used topically for treatment of some kinds of skin problems in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-02-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2019.1692125 |
| _version_ | 1797683647867781120 |
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| author | Rasoul Shakiba Mohammad Ali Nilforoushzadeh Fataneh Hashem-Dabaghian Bagher Minaii Zangii Ali Ghobadi Laila Shirbeigi Jale Aliasl Mahdad Shakiba Roshanak Ghods |
| author_facet | Rasoul Shakiba Mohammad Ali Nilforoushzadeh Fataneh Hashem-Dabaghian Bagher Minaii Zangii Ali Ghobadi Laila Shirbeigi Jale Aliasl Mahdad Shakiba Roshanak Ghods |
| author_sort | Rasoul Shakiba |
| collection | DOAJ |
| description | Background Acne is the most prevalent skin disease in the world and antibiotics as its standard treatments have limited and also adverse effects. Cedar (Ziziphus spina-christi) has medicinal properties like antibacterial activity and is used topically for treatment of some kinds of skin problems in Persian medicine. The aim of this study was to evaluation the efficacy of topical cedar solution of acne vulgaris. Methods Eighty patients aged between 15–45 years with mild to moderate acne vulgaris were conducted in this randomized, double blind trial. The participants were allocated to receive the topical cedar solution plus clindamycin 1% or topical placebo plus 1% clindamycin solution for six weeks. Patients were evaluated at the beginning of the study, second, sixth and eighth weeks after intervention for the acne severity index (ASI) and total acne lesions counting (TLC). Data was analyzed by SPSS software with Mann–Whitney U test. Results From 105 subjects 68 people completed the study (33 persons in cedar group and 35 persons in placebo group). The mean and standard deviation of the age was 26.1 ± 7.5 years and 22 subjects (32.4%) were male. TLC and ASI in the sixth and eighth weeks in cedar group were significantly less than in placebo group (p < 0.001). Topical cedar solution had no serious side effects. Conclusion The topical cedar solution plus clindamycin 1% was more effective and safe than placebo plus 1% clindamycin for the treatment of acne vulgaris. |
| first_indexed | 2024-03-12T00:17:36Z |
| format | Article |
| id | doaj.art-f73a9ede3ca143dfb9c5c67c9e21f8e7 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:17:36Z |
| publishDate | 2021-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-f73a9ede3ca143dfb9c5c67c9e21f8e72023-09-15T14:23:04ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532021-02-0132219720210.1080/09546634.2019.16921251692125Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical studyRasoul Shakiba0Mohammad Ali Nilforoushzadeh1Fataneh Hashem-Dabaghian2Bagher Minaii Zangii3Ali Ghobadi4Laila Shirbeigi5Jale Aliasl6Mahdad Shakiba7Roshanak Ghods8Research Institute for Islamic and Complementary Medicine, Iran University of Medical SciencesSkin and Stem Cell Research Center, Tehran University of Medical SciencesResearch Institute for Islamic and Complementary Medicine, Iran University of Medical SciencesDepartment of Histology, Faculty of Medicine, Tehran University of Medical SciencesResearch Institute for Islamic and Complementary Medicine, Iran University of Medical SciencesDepartment of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical SciencesTraditional Medicine Clinical Trial Research Center, Shahed UniversitySchool of Pharmacy, International Campus, Tehran University of Medical SciencesResearch Institute for Islamic and Complementary Medicine, Iran University of Medical SciencesBackground Acne is the most prevalent skin disease in the world and antibiotics as its standard treatments have limited and also adverse effects. Cedar (Ziziphus spina-christi) has medicinal properties like antibacterial activity and is used topically for treatment of some kinds of skin problems in Persian medicine. The aim of this study was to evaluation the efficacy of topical cedar solution of acne vulgaris. Methods Eighty patients aged between 15–45 years with mild to moderate acne vulgaris were conducted in this randomized, double blind trial. The participants were allocated to receive the topical cedar solution plus clindamycin 1% or topical placebo plus 1% clindamycin solution for six weeks. Patients were evaluated at the beginning of the study, second, sixth and eighth weeks after intervention for the acne severity index (ASI) and total acne lesions counting (TLC). Data was analyzed by SPSS software with Mann–Whitney U test. Results From 105 subjects 68 people completed the study (33 persons in cedar group and 35 persons in placebo group). The mean and standard deviation of the age was 26.1 ± 7.5 years and 22 subjects (32.4%) were male. TLC and ASI in the sixth and eighth weeks in cedar group were significantly less than in placebo group (p < 0.001). Topical cedar solution had no serious side effects. Conclusion The topical cedar solution plus clindamycin 1% was more effective and safe than placebo plus 1% clindamycin for the treatment of acne vulgaris.http://dx.doi.org/10.1080/09546634.2019.1692125acnecedarpersian medicineziziphus spina-christi |
| spellingShingle | Rasoul Shakiba Mohammad Ali Nilforoushzadeh Fataneh Hashem-Dabaghian Bagher Minaii Zangii Ali Ghobadi Laila Shirbeigi Jale Aliasl Mahdad Shakiba Roshanak Ghods Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study Journal of Dermatological Treatment acne cedar persian medicine ziziphus spina-christi |
| title | Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study |
| title_full | Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study |
| title_fullStr | Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study |
| title_full_unstemmed | Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study |
| title_short | Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study |
| title_sort | effect of cedar ziziphus spina christi topical solution in mild to moderate acne vulgaris a randomized clinical study |
| topic | acne cedar persian medicine ziziphus spina-christi |
| url | http://dx.doi.org/10.1080/09546634.2019.1692125 |
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