Viscosity-Regulated Control of RNA Microstructure Fabrication
The development of RNA self-assemblies offers a powerful platform for a wide range of biomedical applications. The fabrication process has become more elaborate in order to achieve functional structures with maximized potential. As a facile means to control the structure, here, we report a new appro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/13/3/454 |
| _version_ | 1797417477845549056 |
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| author | Sunghyun Moon Hyejin Kim Dajeong Kim Jong Bum Lee |
| author_facet | Sunghyun Moon Hyejin Kim Dajeong Kim Jong Bum Lee |
| author_sort | Sunghyun Moon |
| collection | DOAJ |
| description | The development of RNA self-assemblies offers a powerful platform for a wide range of biomedical applications. The fabrication process has become more elaborate in order to achieve functional structures with maximized potential. As a facile means to control the structure, here, we report a new approach to manipulate the polymerization rate and subsequent self-assembly process through regulation of the reaction viscosity. As the RNA polymerization rate has a dependence on solution viscosity, the resulting assembly, crystallization, and overall sizes of the product could be manipulated. The simple and precise control of RNA polymerization and self-assembly by reaction viscosity will provide a way to widen the utility of RNA-based materials. |
| first_indexed | 2024-03-09T06:19:19Z |
| format | Article |
| id | doaj.art-f73b0a0216c145ae91b25d700641bfbd |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T06:19:19Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-f73b0a0216c145ae91b25d700641bfbd2023-12-03T11:50:12ZengMDPI AGPolymers2073-43602021-01-0113345410.3390/polym13030454Viscosity-Regulated Control of RNA Microstructure FabricationSunghyun Moon0Hyejin Kim1Dajeong Kim2Jong Bum Lee3Department of Chemical Engineering, University of Seoul, Seoul 02504, KoreaDepartment of Chemical Engineering, University of Seoul, Seoul 02504, KoreaDepartment of Chemical Engineering, University of Seoul, Seoul 02504, KoreaDepartment of Chemical Engineering, University of Seoul, Seoul 02504, KoreaThe development of RNA self-assemblies offers a powerful platform for a wide range of biomedical applications. The fabrication process has become more elaborate in order to achieve functional structures with maximized potential. As a facile means to control the structure, here, we report a new approach to manipulate the polymerization rate and subsequent self-assembly process through regulation of the reaction viscosity. As the RNA polymerization rate has a dependence on solution viscosity, the resulting assembly, crystallization, and overall sizes of the product could be manipulated. The simple and precise control of RNA polymerization and self-assembly by reaction viscosity will provide a way to widen the utility of RNA-based materials.https://www.mdpi.com/2073-4360/13/3/454RNA microstructuresviscosityreaction controlRNA self-assembliescrystallization |
| spellingShingle | Sunghyun Moon Hyejin Kim Dajeong Kim Jong Bum Lee Viscosity-Regulated Control of RNA Microstructure Fabrication Polymers RNA microstructures viscosity reaction control RNA self-assemblies crystallization |
| title | Viscosity-Regulated Control of RNA Microstructure Fabrication |
| title_full | Viscosity-Regulated Control of RNA Microstructure Fabrication |
| title_fullStr | Viscosity-Regulated Control of RNA Microstructure Fabrication |
| title_full_unstemmed | Viscosity-Regulated Control of RNA Microstructure Fabrication |
| title_short | Viscosity-Regulated Control of RNA Microstructure Fabrication |
| title_sort | viscosity regulated control of rna microstructure fabrication |
| topic | RNA microstructures viscosity reaction control RNA self-assemblies crystallization |
| url | https://www.mdpi.com/2073-4360/13/3/454 |
| work_keys_str_mv | AT sunghyunmoon viscosityregulatedcontrolofrnamicrostructurefabrication AT hyejinkim viscosityregulatedcontrolofrnamicrostructurefabrication AT dajeongkim viscosityregulatedcontrolofrnamicrostructurefabrication AT jongbumlee viscosityregulatedcontrolofrnamicrostructurefabrication |