Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland
Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and huma...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2012-03-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/18/3/11-1236_article |
| _version_ | 1831788226920054784 |
|---|---|
| author | Margo E. Chase-Topping Tracy Rosser Lesley J. Allison Emily Courcier Judith Evans Iain J. McKendrick Michael C. Pearce Ian Handel Alfredo Caprioli Helge Karch Mary F. Hanson Kevin G.J. Pollock Mary E. Locking Mark E.J. Woolhouse Louise Matthews J. Chris Low David L. Gally |
| author_facet | Margo E. Chase-Topping Tracy Rosser Lesley J. Allison Emily Courcier Judith Evans Iain J. McKendrick Michael C. Pearce Ian Handel Alfredo Caprioli Helge Karch Mary F. Hanson Kevin G.J. Pollock Mary E. Locking Mark E.J. Woolhouse Louise Matthews J. Chris Low David L. Gally |
| author_sort | Margo E. Chase-Topping |
| collection | DOAJ |
| description | Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx2 in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26–associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx2 phage acquisition. |
| first_indexed | 2024-12-22T13:44:34Z |
| format | Article |
| id | doaj.art-f73b36c2872c4409a6da7b67834ee7e1 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-22T13:44:34Z |
| publishDate | 2012-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-f73b36c2872c4409a6da7b67834ee7e12022-12-21T18:23:50ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592012-03-0118343944810.3201/eid1803.111236Pathogenic Potential to Humans of Bovine Escherichia coli O26, ScotlandMargo E. Chase-ToppingTracy RosserLesley J. AllisonEmily CourcierJudith EvansIain J. McKendrickMichael C. PearceIan HandelAlfredo CaprioliHelge KarchMary F. HansonKevin G.J. PollockMary E. LockingMark E.J. WoolhouseLouise MatthewsJ. Chris LowDavid L. GallyEscherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx2 in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26–associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx2 phage acquisition.https://wwwnc.cdc.gov/eid/article/18/3/11-1236_articleEscherichia coli O26Escherichia coli O157prevalencepulsed-field gel electrophoresisPFGEmultilocus sequence typing |
| spellingShingle | Margo E. Chase-Topping Tracy Rosser Lesley J. Allison Emily Courcier Judith Evans Iain J. McKendrick Michael C. Pearce Ian Handel Alfredo Caprioli Helge Karch Mary F. Hanson Kevin G.J. Pollock Mary E. Locking Mark E.J. Woolhouse Louise Matthews J. Chris Low David L. Gally Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland Emerging Infectious Diseases Escherichia coli O26 Escherichia coli O157 prevalence pulsed-field gel electrophoresis PFGE multilocus sequence typing |
| title | Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland |
| title_full | Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland |
| title_fullStr | Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland |
| title_full_unstemmed | Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland |
| title_short | Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland |
| title_sort | pathogenic potential to humans of bovine escherichia coli o26 scotland |
| topic | Escherichia coli O26 Escherichia coli O157 prevalence pulsed-field gel electrophoresis PFGE multilocus sequence typing |
| url | https://wwwnc.cdc.gov/eid/article/18/3/11-1236_article |
| work_keys_str_mv | AT margoechasetopping pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT tracyrosser pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT lesleyjallison pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT emilycourcier pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT judithevans pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT iainjmckendrick pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT michaelcpearce pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT ianhandel pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT alfredocaprioli pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT helgekarch pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT maryfhanson pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT kevingjpollock pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT maryelocking pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT markejwoolhouse pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT louisematthews pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT jchrislow pathogenicpotentialtohumansofbovineescherichiacolio26scotland AT davidlgally pathogenicpotentialtohumansofbovineescherichiacolio26scotland |