TRPM Family Channels in Cancer
Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers such...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | http://www.mdpi.com/1424-8247/11/2/58 |
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| author | Aline Hantute-Ghesquier Aurélien Haustrate Natalia Prevarskaya V’yacheslav Lehen’kyi |
| author_facet | Aline Hantute-Ghesquier Aurélien Haustrate Natalia Prevarskaya V’yacheslav Lehen’kyi |
| author_sort | Aline Hantute-Ghesquier |
| collection | DOAJ |
| description | Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers such as prostate cancer for mostly TRPM8 and TRPM2, breast cancer for mostly TRPM2 and TRPM7, and pancreatic cancer for TRPM2/7/8 channels. The role of TRPM5 channels has been shown in lung cancer, TRPM1 in melanoma, and TRPM4 channel in prostate cancer as well. Thus, the TRPM family of channels may represent an appealing target for the anticancer therapy. |
| first_indexed | 2024-04-13T17:25:33Z |
| format | Article |
| id | doaj.art-f73cc3ea373e400e956bcecd516e4c9b |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-04-13T17:25:33Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-f73cc3ea373e400e956bcecd516e4c9b2022-12-22T02:37:49ZengMDPI AGPharmaceuticals1424-82472018-06-011125810.3390/ph11020058ph11020058TRPM Family Channels in CancerAline Hantute-Ghesquier0Aurélien Haustrate1Natalia Prevarskaya2V’yacheslav Lehen’kyi3Laboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceLaboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceLaboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceLaboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceMembers of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers such as prostate cancer for mostly TRPM8 and TRPM2, breast cancer for mostly TRPM2 and TRPM7, and pancreatic cancer for TRPM2/7/8 channels. The role of TRPM5 channels has been shown in lung cancer, TRPM1 in melanoma, and TRPM4 channel in prostate cancer as well. Thus, the TRPM family of channels may represent an appealing target for the anticancer therapy.http://www.mdpi.com/1424-8247/11/2/58TRPM channelscancertargettherapy |
| spellingShingle | Aline Hantute-Ghesquier Aurélien Haustrate Natalia Prevarskaya V’yacheslav Lehen’kyi TRPM Family Channels in Cancer Pharmaceuticals TRPM channels cancer target therapy |
| title | TRPM Family Channels in Cancer |
| title_full | TRPM Family Channels in Cancer |
| title_fullStr | TRPM Family Channels in Cancer |
| title_full_unstemmed | TRPM Family Channels in Cancer |
| title_short | TRPM Family Channels in Cancer |
| title_sort | trpm family channels in cancer |
| topic | TRPM channels cancer target therapy |
| url | http://www.mdpi.com/1424-8247/11/2/58 |
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