Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis
The homeostasis of calcium (Ca) and iron (Fe) is disturbed during menopause. The present study aimed to determine the effects of Ca-enriched pumpkin on Fe status in ovariectomized rats. A total of 48 female Wistar rats were divided into six groups. One group was fed a standard diet (C), while the ot...
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-04-01
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| Series: | Open Chemistry |
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| Online Access: | https://doi.org/10.1515/chem-2022-0314 |
| _version_ | 1797832529045094400 |
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| author | Wawrzyniak Natalia Gramza-Michałowska Anna Suliburska Joanna |
| author_facet | Wawrzyniak Natalia Gramza-Michałowska Anna Suliburska Joanna |
| author_sort | Wawrzyniak Natalia |
| collection | DOAJ |
| description | The homeostasis of calcium (Ca) and iron (Fe) is disturbed during menopause. The present study aimed to determine the effects of Ca-enriched pumpkin on Fe status in ovariectomized rats. A total of 48 female Wistar rats were divided into six groups. One group was fed a standard diet (C), while the other five groups were ovariectomized and fed a standard diet (OVX), a calcium lactate diet (CaL_OVX), calcium lactate-enriched pumpkin (PCaL_OVX), calcium lactate and alendronate (CaL_OVX_B), and calcium lactate-enriched pumpkin and alendronate (PCaL_OVX_B), respectively. The nutritional intervention lasted 12 weeks and rats were euthanized. Tissue samples were collected, and the iron content in the samples was assessed. A comparison of all groups showed a reduction in iron concentrations in femurs, liver, hair, spleen, and kidneys in the ovariectomized groups than in the control group. The PCaL_OVX_B group had a significantly higher blood hemoglobin concentration than the control group. Moreover, spleen and liver Fe concentrations were the highest in PCaL_OVX and PCaL_OVX_B rats among the treated groups and were comparable with the control group. These results indicate that ovariectomy decreases Fe status in rats. Calcium lactate-enriched pumpkin with and without alendronate can increase Fe concentration in liver and spleen in ovariectomized rats. |
| first_indexed | 2024-04-09T14:10:26Z |
| format | Article |
| id | doaj.art-f73d959b28104603a71ca80c7dcdd437 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-04-09T14:10:26Z |
| publishDate | 2023-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-f73d959b28104603a71ca80c7dcdd4372023-05-06T15:31:53ZengDe GruyterOpen Chemistry2391-54202023-04-012111376710.1515/chem-2022-0314Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosisWawrzyniak Natalia0Gramza-Michałowska Anna1Suliburska Joanna2Department of Human Nutrition and Dietetics, Faculty of Food and Nutrition Science, University of Life Sciences, 60-624 Poznan, PolandDepartment of Gastronomy Sciences and Functional Foods, Faculty of Food and Nutrition Science, University of Life Sciences, 60-624 Poznan, PolandDepartment of Human Nutrition and Dietetics, Faculty of Food and Nutrition Science, University of Life Sciences, 60-624 Poznan, PolandThe homeostasis of calcium (Ca) and iron (Fe) is disturbed during menopause. The present study aimed to determine the effects of Ca-enriched pumpkin on Fe status in ovariectomized rats. A total of 48 female Wistar rats were divided into six groups. One group was fed a standard diet (C), while the other five groups were ovariectomized and fed a standard diet (OVX), a calcium lactate diet (CaL_OVX), calcium lactate-enriched pumpkin (PCaL_OVX), calcium lactate and alendronate (CaL_OVX_B), and calcium lactate-enriched pumpkin and alendronate (PCaL_OVX_B), respectively. The nutritional intervention lasted 12 weeks and rats were euthanized. Tissue samples were collected, and the iron content in the samples was assessed. A comparison of all groups showed a reduction in iron concentrations in femurs, liver, hair, spleen, and kidneys in the ovariectomized groups than in the control group. The PCaL_OVX_B group had a significantly higher blood hemoglobin concentration than the control group. Moreover, spleen and liver Fe concentrations were the highest in PCaL_OVX and PCaL_OVX_B rats among the treated groups and were comparable with the control group. These results indicate that ovariectomy decreases Fe status in rats. Calcium lactate-enriched pumpkin with and without alendronate can increase Fe concentration in liver and spleen in ovariectomized rats.https://doi.org/10.1515/chem-2022-0314iron metabolismovariectomyenriched pumpkincalcium |
| spellingShingle | Wawrzyniak Natalia Gramza-Michałowska Anna Suliburska Joanna Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis Open Chemistry iron metabolism ovariectomy enriched pumpkin calcium |
| title | Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis |
| title_full | Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis |
| title_fullStr | Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis |
| title_full_unstemmed | Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis |
| title_short | Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis |
| title_sort | effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis |
| topic | iron metabolism ovariectomy enriched pumpkin calcium |
| url | https://doi.org/10.1515/chem-2022-0314 |
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