Analysis of Memory-Related Brain Activation Maps in Sleep-Depriveation using Functional Magnetic Resonance Imaging
Background and purpose: Insomnia is a common sleep disorder with negative consequences such as decreased quality of life. In this study, the effect of sleep deprivation on memory in both young and older adults was investigated using functional magnetic resonance imaging (fMRI). Materials and methods...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2023-01-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-18637-en.pdf |
| _version_ | 1797542783916965888 |
|---|---|
| author | Rezvan Safari Hamid Sharini Mehdi Khodamoradi Meysam Siyah Mansoory |
| author_facet | Rezvan Safari Hamid Sharini Mehdi Khodamoradi Meysam Siyah Mansoory |
| author_sort | Rezvan Safari |
| collection | DOAJ |
| description | Background and purpose: Insomnia is a common sleep disorder with negative consequences such as decreased quality of life. In this study, the effect of sleep deprivation on memory in both young and older adults was investigated using functional magnetic resonance imaging (fMRI).
Materials and methods: In this retrospective study, fMRI data of 40 healthy subjects (17 young and 23 older people) who had a one-month sleep deprivation period (during the experiment they woke up three hours earlier than usual) were obtained. Then, pre-processing was done to remove artifacts and noise. Finally, data processing was completed in order to extract the brain activity map focusing on brain areas related to memory.
Results: Findings showed that the brain activity of most areas are reduced due to insomnia. In the young group, 17 functional connections were obtained at the beginning of the study which decreased to only one connection after the insomnia period. In older adults there were seven connections at the beginning of the study that decreased to four after the insomnia period (P< 0.05).
Conclusion: Brain map analysis, including connections and activity levels of memory-related areas, showed that sleep deprivation affects the brains of young and old people. Our findings can pave the way for future studies to understand the effect of insomnia on memory and brain. |
| first_indexed | 2024-03-10T13:35:24Z |
| format | Article |
| id | doaj.art-f73e622d24f745a7a429f58baf6a736c |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-10T13:35:24Z |
| publishDate | 2023-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-f73e622d24f745a7a429f58baf6a736c2023-11-21T07:39:55ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-01-0132216115127Analysis of Memory-Related Brain Activation Maps in Sleep-Depriveation using Functional Magnetic Resonance ImagingRezvan Safari0Hamid Sharini1Mehdi Khodamoradi2Meysam Siyah Mansoory3 MSc in Biomedical Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Assistant Professor, Department of Biomedical Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Assistant Professor, Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Assistant Professor, Department of Biomedical Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Background and purpose: Insomnia is a common sleep disorder with negative consequences such as decreased quality of life. In this study, the effect of sleep deprivation on memory in both young and older adults was investigated using functional magnetic resonance imaging (fMRI). Materials and methods: In this retrospective study, fMRI data of 40 healthy subjects (17 young and 23 older people) who had a one-month sleep deprivation period (during the experiment they woke up three hours earlier than usual) were obtained. Then, pre-processing was done to remove artifacts and noise. Finally, data processing was completed in order to extract the brain activity map focusing on brain areas related to memory. Results: Findings showed that the brain activity of most areas are reduced due to insomnia. In the young group, 17 functional connections were obtained at the beginning of the study which decreased to only one connection after the insomnia period. In older adults there were seven connections at the beginning of the study that decreased to four after the insomnia period (P< 0.05). Conclusion: Brain map analysis, including connections and activity levels of memory-related areas, showed that sleep deprivation affects the brains of young and old people. Our findings can pave the way for future studies to understand the effect of insomnia on memory and brain.http://jmums.mazums.ac.ir/article-1-18637-en.pdfmemorysleep deprivationbrain activitybrain connectivityfunctional magnetic resonance imaging |
| spellingShingle | Rezvan Safari Hamid Sharini Mehdi Khodamoradi Meysam Siyah Mansoory Analysis of Memory-Related Brain Activation Maps in Sleep-Depriveation using Functional Magnetic Resonance Imaging Journal of Mazandaran University of Medical Sciences memory sleep deprivation brain activity brain connectivity functional magnetic resonance imaging |
| title | Analysis of Memory-Related Brain Activation Maps in Sleep-Depriveation using Functional Magnetic Resonance Imaging |
| title_full | Analysis of Memory-Related Brain Activation Maps in Sleep-Depriveation using Functional Magnetic Resonance Imaging |
| title_fullStr | Analysis of Memory-Related Brain Activation Maps in Sleep-Depriveation using Functional Magnetic Resonance Imaging |
| title_full_unstemmed | Analysis of Memory-Related Brain Activation Maps in Sleep-Depriveation using Functional Magnetic Resonance Imaging |
| title_short | Analysis of Memory-Related Brain Activation Maps in Sleep-Depriveation using Functional Magnetic Resonance Imaging |
| title_sort | analysis of memory related brain activation maps in sleep depriveation using functional magnetic resonance imaging |
| topic | memory sleep deprivation brain activity brain connectivity functional magnetic resonance imaging |
| url | http://jmums.mazums.ac.ir/article-1-18637-en.pdf |
| work_keys_str_mv | AT rezvansafari analysisofmemoryrelatedbrainactivationmapsinsleepdepriveationusingfunctionalmagneticresonanceimaging AT hamidsharini analysisofmemoryrelatedbrainactivationmapsinsleepdepriveationusingfunctionalmagneticresonanceimaging AT mehdikhodamoradi analysisofmemoryrelatedbrainactivationmapsinsleepdepriveationusingfunctionalmagneticresonanceimaging AT meysamsiyahmansoory analysisofmemoryrelatedbrainactivationmapsinsleepdepriveationusingfunctionalmagneticresonanceimaging |