Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies
RNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb su...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/10/2200 |
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| author | Kavitha Ramaswamy Mariya Rashid Selvarajan Ramasamy Tamilselvan Jayavelu Sangita Venkataraman |
| author_facet | Kavitha Ramaswamy Mariya Rashid Selvarajan Ramasamy Tamilselvan Jayavelu Sangita Venkataraman |
| author_sort | Kavitha Ramaswamy |
| collection | DOAJ |
| description | RNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb subdomains. Despite the presence of a common structural core, the RdRPs differ significantly in the mechanistic details of RNA binding and polymerization. The present review aims at exploring these incongruities in light of recent structural studies of RdRP complexes with diverse cofactors, RNA moieties, analogs, and inhibitors. |
| first_indexed | 2024-03-09T19:23:29Z |
| format | Article |
| id | doaj.art-f73f9ae8cb0945c78fa2d03a56108ed9 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T19:23:29Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f73f9ae8cb0945c78fa2d03a56108ed92023-11-24T03:09:14ZengMDPI AGViruses1999-49152022-10-011410220010.3390/v14102200Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural StudiesKavitha Ramaswamy0Mariya Rashid1Selvarajan Ramasamy2Tamilselvan Jayavelu3Sangita Venkataraman4Department of Biotechnology, Anna University, Sardar Patel Road, Guindy, Chennai 600025, IndiaTaiwan International Graduate Program, Molecular Cell Biology (National Defense Medical Center and Academia Sinica), Taipei 115, TaiwanNational Research Center for Banana, Somarasempettai−Thogaimalai Rd, Podavur, Tamil Nadu 639103, IndiaDepartment of Biotechnology, Anna University, Sardar Patel Road, Guindy, Chennai 600025, IndiaDepartment of Biotechnology, Anna University, Sardar Patel Road, Guindy, Chennai 600025, IndiaRNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb subdomains. Despite the presence of a common structural core, the RdRPs differ significantly in the mechanistic details of RNA binding and polymerization. The present review aims at exploring these incongruities in light of recent structural studies of RdRP complexes with diverse cofactors, RNA moieties, analogs, and inhibitors.https://www.mdpi.com/1999-4915/14/10/2200replicationpolymerasecofactorsstructureRNA virusesinhibitors |
| spellingShingle | Kavitha Ramaswamy Mariya Rashid Selvarajan Ramasamy Tamilselvan Jayavelu Sangita Venkataraman Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies Viruses replication polymerase cofactors structure RNA viruses inhibitors |
| title | Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies |
| title_full | Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies |
| title_fullStr | Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies |
| title_full_unstemmed | Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies |
| title_short | Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies |
| title_sort | revisiting viral rna dependent rna polymerases insights from recent structural studies |
| topic | replication polymerase cofactors structure RNA viruses inhibitors |
| url | https://www.mdpi.com/1999-4915/14/10/2200 |
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