Successful Rescue of Synthetic AcMNPV with a ~17 kb Deletion in the C1 Region of the Genome

Successful Rescue of Synthetic AcMNPV with a ~17 kb Deletion in the C1 Region of the Genome

Baculoviruses have been widely used as expression vectors. However, numerous genes in the baculoviral genome are non-essential for cellular infection and protein expression, making the optimisation of baculovirus expression vectors possible. We used a synthetic biological method to reduce the number...

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Bibliographic Details
Main Authors: Yijia Guo, Hengrui Hu, Han Xiao, Fei Deng, Jiang Li, Manli Wang, Zhihong Hu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
baculoviruses
synthetic genome
non-essential genes
genome reduction
Online Access:https://www.mdpi.com/1999-4915/14/12/2780

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