Association of ABO blood group with susceptibility to SARS-CoV-2 infection in Rupandehi district of Nepal
Objectives: Recent studies after the outbreak of coronavirus disease 2019 have shown an association of the ABO blood group to the susceptibility of severe acute respiratory syndrome coronavirus 2 infection. Anti-A and anti-B antibodies, carbohydrate clustering, interleukin-6 levels and host transmem...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-04-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121221095413 |
| _version_ | 1818263583406948352 |
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| author | Sanyukta Gurung Narayan Bahadur Mahotra Lava Shrestha Aakash Sherpali Surya Prakash Joshi Gambhir Shrestha Shailesh Shrestha Aman Shakya Manoj Kandel |
| author_facet | Sanyukta Gurung Narayan Bahadur Mahotra Lava Shrestha Aakash Sherpali Surya Prakash Joshi Gambhir Shrestha Shailesh Shrestha Aman Shakya Manoj Kandel |
| author_sort | Sanyukta Gurung |
| collection | DOAJ |
| description | Objectives: Recent studies after the outbreak of coronavirus disease 2019 have shown an association of the ABO blood group to the susceptibility of severe acute respiratory syndrome coronavirus 2 infection. Anti-A and anti-B antibodies, carbohydrate clustering, interleukin-6 levels and host transmembrane protease serine subtype 2 were suggested to cause the variable susceptibility of severe acute respiratory syndrome coronavirus 2 infection to the ABO blood groups. This study aims to find the association of the ABO blood group with severe acute respiratory syndrome coronavirus 2 infection susceptibility in Nepal. Methods: Population-based matched case–control study was conducted from October 2021 to February 2022 in Rupandehi district of Nepal. A total of 1091 reverse transcription-polymerase chain reaction confirmed coronavirus disease 2019 cases and 2182 controls were included in the study by convenient sampling method. Results: A statistically significant association of severe acute respiratory syndrome coronavirus 2 infection was observed for the blood group AB between cases and controls (11.5% vs 8.5%; odds ratio = 1.4, 95% confidence interval = 1.10–1.78). However, there was no association of severe acute respiratory syndrome coronavirus 2 infection for blood group A (26.7% vs 28.23%; odds ratio = 0.93, 95% confidence interval = 0.79–1.09), B (26.9% vs 29.84%; odds ratio = 0.86, 95% confidence interval = 0.73–1.02) and O (34.9% vs 33.41%; odds ratio = 1.07, 95% confidence interval = 0.92–1.25). Conclusion: This study reported slightly more susceptibility to severe acute respiratory syndrome coronavirus 2 infection among individuals with blood group AB. |
| first_indexed | 2024-12-12T19:21:19Z |
| format | Article |
| id | doaj.art-f74100eb76ea4cd680ecb5094fbcc671 |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-12-12T19:21:19Z |
| publishDate | 2022-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-f74100eb76ea4cd680ecb5094fbcc6712022-12-22T00:14:36ZengSAGE PublishingSAGE Open Medicine2050-31212022-04-011010.1177/20503121221095413Association of ABO blood group with susceptibility to SARS-CoV-2 infection in Rupandehi district of NepalSanyukta Gurung0Narayan Bahadur Mahotra1Lava Shrestha2Aakash Sherpali3Surya Prakash Joshi4Gambhir Shrestha5Shailesh Shrestha6Aman Shakya7Manoj Kandel8Department of Clinical Physiology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, NepalDepartment of Clinical Physiology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, NepalDepartment of Clinical Physiology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, NepalMaharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, NepalMaharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, NepalDepartment of Community Medicine, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, NepalDepartment of Clinical Psychology, Tri-Chandra College, Tribhuvan University, Kathmandu, NepalDepartment of Clinical Physiology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, NepalDepartment of Biomedical Engineering and Environmental Science, National Tsing Hua University, HsinchuObjectives: Recent studies after the outbreak of coronavirus disease 2019 have shown an association of the ABO blood group to the susceptibility of severe acute respiratory syndrome coronavirus 2 infection. Anti-A and anti-B antibodies, carbohydrate clustering, interleukin-6 levels and host transmembrane protease serine subtype 2 were suggested to cause the variable susceptibility of severe acute respiratory syndrome coronavirus 2 infection to the ABO blood groups. This study aims to find the association of the ABO blood group with severe acute respiratory syndrome coronavirus 2 infection susceptibility in Nepal. Methods: Population-based matched case–control study was conducted from October 2021 to February 2022 in Rupandehi district of Nepal. A total of 1091 reverse transcription-polymerase chain reaction confirmed coronavirus disease 2019 cases and 2182 controls were included in the study by convenient sampling method. Results: A statistically significant association of severe acute respiratory syndrome coronavirus 2 infection was observed for the blood group AB between cases and controls (11.5% vs 8.5%; odds ratio = 1.4, 95% confidence interval = 1.10–1.78). However, there was no association of severe acute respiratory syndrome coronavirus 2 infection for blood group A (26.7% vs 28.23%; odds ratio = 0.93, 95% confidence interval = 0.79–1.09), B (26.9% vs 29.84%; odds ratio = 0.86, 95% confidence interval = 0.73–1.02) and O (34.9% vs 33.41%; odds ratio = 1.07, 95% confidence interval = 0.92–1.25). Conclusion: This study reported slightly more susceptibility to severe acute respiratory syndrome coronavirus 2 infection among individuals with blood group AB.https://doi.org/10.1177/20503121221095413 |
| spellingShingle | Sanyukta Gurung Narayan Bahadur Mahotra Lava Shrestha Aakash Sherpali Surya Prakash Joshi Gambhir Shrestha Shailesh Shrestha Aman Shakya Manoj Kandel Association of ABO blood group with susceptibility to SARS-CoV-2 infection in Rupandehi district of Nepal SAGE Open Medicine |
| title | Association of ABO blood group with susceptibility to SARS-CoV-2 infection in Rupandehi district of Nepal |
| title_full | Association of ABO blood group with susceptibility to SARS-CoV-2 infection in Rupandehi district of Nepal |
| title_fullStr | Association of ABO blood group with susceptibility to SARS-CoV-2 infection in Rupandehi district of Nepal |
| title_full_unstemmed | Association of ABO blood group with susceptibility to SARS-CoV-2 infection in Rupandehi district of Nepal |
| title_short | Association of ABO blood group with susceptibility to SARS-CoV-2 infection in Rupandehi district of Nepal |
| title_sort | association of abo blood group with susceptibility to sars cov 2 infection in rupandehi district of nepal |
| url | https://doi.org/10.1177/20503121221095413 |
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