Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery
Aim of the study: In selected surgical neonates and infants, the rapidity of induction and intubation may represent an important factor for their safety. Propofol is an anesthetic characterized by a rapid onset and fast recovery time that may reduce time of anesthetic induction and improve post-anes...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2019.00321/full |
| _version_ | 1811260889336119296 |
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| author | Stefania Sgrò Francesco Morini Patrizia Bozza Fiammetta Piersigilli Pietro Bagolan Sergio Picardo |
| author_facet | Stefania Sgrò Francesco Morini Patrizia Bozza Fiammetta Piersigilli Pietro Bagolan Sergio Picardo |
| author_sort | Stefania Sgrò |
| collection | DOAJ |
| description | Aim of the study: In selected surgical neonates and infants, the rapidity of induction and intubation may represent an important factor for their safety. Propofol is an anesthetic characterized by a rapid onset and fast recovery time that may reduce time of anesthetic induction and improve post-anesthetic outcome. The aim of this study was to evaluate the safety and efficacy of anesthesia induction in full-term neonates and young infants after propofol bolus administration.Methods: A retrospective case-control study including infants below 6 months of age, undergoing general anesthesia between 2011 and 2013, was carried out. Patients that received intravenous propofol bolus to induce anesthesia were compared to patients who received inhaled sevoflurane. Time to reach successful orotracheal intubation (OTI) was measured in seconds. The quality of OTI was defined as “excellent,” “good,” and “poor,” based on established classification and was reported. Hemodynamic parameters as systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), heart rate (HR), and oxygen saturation (SaO2) were collected before OTI (t0), at OTI (t1), and at spontaneous breathing recovery (t2). Main adverse effects were recorded for both groups. Results are median (IQ range) or prevalence; p < 0.05 was considered significant.Results: 160 infants were enrolled in the study, 80 received propofol and 80 inhaled sevoflurane. Major surgery (involving organs in the thoracic, abdominal, or pelvic cavities) was performed in 64 and 54% of patients in the propofol and sevoflurane group, respectively (p = 0.07). Patients in the propofol group showed a shorter time for OTI [11.5 (4.0–65) vs. 360.0 (228.0–720.0) seconds, (p < 0.0001)]. No difference was found in the quality of OTI between the two groups. No significant complications were recorded in either group.Conclusions: Propofol is a safe and effective anesthetic in neonates and infants permitting rapid induction of anesthesia and rapid intubation, without negative impact on the quality of intubation and haemodynamic compromise. |
| first_indexed | 2024-04-12T18:55:22Z |
| format | Article |
| id | doaj.art-f7411704bbaa49f28d22d7737c516d09 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T18:55:22Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-f7411704bbaa49f28d22d7737c516d092022-12-22T03:20:22ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602019-08-01710.3389/fped.2019.00321425288Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major SurgeryStefania Sgrò0Francesco Morini1Patrizia Bozza2Fiammetta Piersigilli3Pietro Bagolan4Sergio Picardo5Department of Anesthesia and Critical Care, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, ItalyDepartment of Medical and Surgical Neonatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, ItalyDepartment of Anesthesia and Critical Care, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, ItalyDepartment of Medical and Surgical Neonatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, ItalyDepartment of Medical and Surgical Neonatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, ItalyDepartment of Anesthesia and Critical Care, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, ItalyAim of the study: In selected surgical neonates and infants, the rapidity of induction and intubation may represent an important factor for their safety. Propofol is an anesthetic characterized by a rapid onset and fast recovery time that may reduce time of anesthetic induction and improve post-anesthetic outcome. The aim of this study was to evaluate the safety and efficacy of anesthesia induction in full-term neonates and young infants after propofol bolus administration.Methods: A retrospective case-control study including infants below 6 months of age, undergoing general anesthesia between 2011 and 2013, was carried out. Patients that received intravenous propofol bolus to induce anesthesia were compared to patients who received inhaled sevoflurane. Time to reach successful orotracheal intubation (OTI) was measured in seconds. The quality of OTI was defined as “excellent,” “good,” and “poor,” based on established classification and was reported. Hemodynamic parameters as systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), heart rate (HR), and oxygen saturation (SaO2) were collected before OTI (t0), at OTI (t1), and at spontaneous breathing recovery (t2). Main adverse effects were recorded for both groups. Results are median (IQ range) or prevalence; p < 0.05 was considered significant.Results: 160 infants were enrolled in the study, 80 received propofol and 80 inhaled sevoflurane. Major surgery (involving organs in the thoracic, abdominal, or pelvic cavities) was performed in 64 and 54% of patients in the propofol and sevoflurane group, respectively (p = 0.07). Patients in the propofol group showed a shorter time for OTI [11.5 (4.0–65) vs. 360.0 (228.0–720.0) seconds, (p < 0.0001)]. No difference was found in the quality of OTI between the two groups. No significant complications were recorded in either group.Conclusions: Propofol is a safe and effective anesthetic in neonates and infants permitting rapid induction of anesthesia and rapid intubation, without negative impact on the quality of intubation and haemodynamic compromise.https://www.frontiersin.org/article/10.3389/fped.2019.00321/fullpropofolsevofluraneneonatesinduction agentintubation |
| spellingShingle | Stefania Sgrò Francesco Morini Patrizia Bozza Fiammetta Piersigilli Pietro Bagolan Sergio Picardo Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery Frontiers in Pediatrics propofol sevoflurane neonates induction agent intubation |
| title | Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery |
| title_full | Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery |
| title_fullStr | Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery |
| title_full_unstemmed | Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery |
| title_short | Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery |
| title_sort | intravenous propofol allows fast intubation in neonates and young infants undergoing major surgery |
| topic | propofol sevoflurane neonates induction agent intubation |
| url | https://www.frontiersin.org/article/10.3389/fped.2019.00321/full |
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