Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). In the brain, SAM donates methyl groups to catechol-O-methyltransferase (COMT),...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-06-01
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| Series: | Molecular Genetics and Metabolism Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214426915000087 |
| _version_ | 1811223281157537792 |
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| author | N.M. Jadavji F. Wieske U. Dirnagl C. Winter |
| author_facet | N.M. Jadavji F. Wieske U. Dirnagl C. Winter |
| author_sort | N.M. Jadavji |
| collection | DOAJ |
| description | Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). In the brain, SAM donates methyl groups to catechol-O-methyltransferase (COMT), which is involved in neurotransmitter analysis. Using the MTHFR-deficient mouse model the purpose of this study was to investigate levels of monoamine neurotransmitters and amino acid levels in brain tissue. MTHFR deficiency affected levels of both glutamate and γ-aminobutyric acid in within the cerebellum and hippocampus. Mthfr−/− mice had reduced levels of glutamate in the amygdala and γ-aminobutyric acid in the thalamus. The excitatory mechanisms of homocysteine through activation of the N-methyl-d-aspartate receptor in brain tissue might alter levels of glutamate and γ-aminobutyric acid. |
| first_indexed | 2024-04-12T08:30:13Z |
| format | Article |
| id | doaj.art-f74149398dbe418894dda5ba724bf420 |
| institution | Directory Open Access Journal |
| issn | 2214-4269 |
| language | English |
| last_indexed | 2024-04-12T08:30:13Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Genetics and Metabolism Reports |
| spelling | doaj.art-f74149398dbe418894dda5ba724bf4202022-12-22T03:40:15ZengElsevierMolecular Genetics and Metabolism Reports2214-42692015-06-013C1410.1016/j.ymgmr.2015.02.001Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissueN.M. Jadavji0F. Wieske1U. Dirnagl2C. Winter3Department of Experimental Neurology, Center for Stroke Research Berlin, Charité University Medicine Berlin, GermanyDepartment of Experimental Psychiatry, University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Dresden, GermanyDepartment of Experimental Neurology, Center for Stroke Research Berlin, Charité University Medicine Berlin, GermanyDepartment of Experimental Psychiatry, University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Dresden, GermanyMethylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). In the brain, SAM donates methyl groups to catechol-O-methyltransferase (COMT), which is involved in neurotransmitter analysis. Using the MTHFR-deficient mouse model the purpose of this study was to investigate levels of monoamine neurotransmitters and amino acid levels in brain tissue. MTHFR deficiency affected levels of both glutamate and γ-aminobutyric acid in within the cerebellum and hippocampus. Mthfr−/− mice had reduced levels of glutamate in the amygdala and γ-aminobutyric acid in the thalamus. The excitatory mechanisms of homocysteine through activation of the N-methyl-d-aspartate receptor in brain tissue might alter levels of glutamate and γ-aminobutyric acid.http://www.sciencedirect.com/science/article/pii/S2214426915000087Methylenetetrahydrofolate reductaseS-AdenosylmethionineHomocysteineMonoamine neurotransmittersGlutamateγ-Aminobutyric acid |
| spellingShingle | N.M. Jadavji F. Wieske U. Dirnagl C. Winter Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue Molecular Genetics and Metabolism Reports Methylenetetrahydrofolate reductase S-Adenosylmethionine Homocysteine Monoamine neurotransmitters Glutamate γ-Aminobutyric acid |
| title | Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue |
| title_full | Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue |
| title_fullStr | Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue |
| title_full_unstemmed | Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue |
| title_short | Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue |
| title_sort | methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ aminobutyric acid in brain tissue |
| topic | Methylenetetrahydrofolate reductase S-Adenosylmethionine Homocysteine Monoamine neurotransmitters Glutamate γ-Aminobutyric acid |
| url | http://www.sciencedirect.com/science/article/pii/S2214426915000087 |
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