Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue

Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). In the brain, SAM donates methyl groups to catechol-O-methyltransferase (COMT),...

Full description

Bibliographic Details
Main Authors: N.M. Jadavji, F. Wieske, U. Dirnagl, C. Winter
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Methylenetetrahydrofolate reductase
S-Adenosylmethionine
Homocysteine
Monoamine neurotransmitters
Glutamate
γ-Aminobutyric acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426915000087

Internet

http://www.sciencedirect.com/science/article/pii/S2214426915000087

Similar Items