Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study
Teucrium polium (germander, Lamiaceae) is a local plant in Qatar that has been used in folk medicine to treat numerous illnesses. It is known for its antioxidant, analgesic, anticancer, and antibacterial activities. This study aimed to evaluate the anti-inflammatory activity of Teucrium polium (TP)...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2024-01-01
|
| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/9239 |
| _version_ | 1797261407379521536 |
|---|---|
| author | Hamda A. Al-Naemi Reem Moath Alasmar Kaltham Al-Ghanim |
| author_facet | Hamda A. Al-Naemi Reem Moath Alasmar Kaltham Al-Ghanim |
| author_sort | Hamda A. Al-Naemi |
| collection | DOAJ |
| description |
Teucrium polium (germander, Lamiaceae) is a local plant in Qatar that has been used in folk medicine to treat numerous illnesses. It is known for its antioxidant, analgesic, anticancer, and antibacterial activities. This study aimed to evaluate the anti-inflammatory activity of Teucrium polium (TP) extract by α-carrageen-induced paw edema in adult Sprague Dawley rats. The animals were randomly grouped into control, acute inflammation, and plant extract groups. Acute inflammation was induced by a sub-plantar injection of 100 µL of 1% α-carrageenan into the rat’s right hind paw. Three different doses of the ethanolic extract of TP were tested at different time periods (1, 3, and 5 hours). All doses of the TP ethanolic extract showed significant inhibition of α-carrageenan-induced rat paw edema in a dose-dependent manner in both early and late phases of edema formation. The size of the α-carrageen induced paw edema was significantly reduced one, three, and five hours after TP extract injection compared to the acute inflammation group. This inhibition was accompanied by high expression of interleukin 10 (IL-10) and low expression of monocyte chemoattractant protein 1 (MCP-1), IL-1β and tumor necrosis factor alpha (TNF-α). The results indicated that the ethanolic extracts of TP possess significant anti-inflammatory and potential pharmaceutical properties.
|
| first_indexed | 2024-04-24T23:40:44Z |
| format | Article |
| id | doaj.art-f741d7ef9e7b48e2b46f106dcebd592f |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:40:44Z |
| publishDate | 2024-01-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-f741d7ef9e7b48e2b46f106dcebd592f2024-03-15T13:21:16ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2024-01-0124110.17305/bb.2023.9239Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo studyHamda A. Al-Naemi0Reem Moath Alasmar1Kaltham Al-Ghanim 2Laboratory Animal Research Centre, Qatar University, Doha, Qatar; Department of Biological and Environmental Sciences, Qatar University, Doha, QatarLaboratory Animal Research Centre, Qatar University, Doha, QatarSocial and Economic Survey Research Institute (SESRI), Qatar University, Doha, Qatar Teucrium polium (germander, Lamiaceae) is a local plant in Qatar that has been used in folk medicine to treat numerous illnesses. It is known for its antioxidant, analgesic, anticancer, and antibacterial activities. This study aimed to evaluate the anti-inflammatory activity of Teucrium polium (TP) extract by α-carrageen-induced paw edema in adult Sprague Dawley rats. The animals were randomly grouped into control, acute inflammation, and plant extract groups. Acute inflammation was induced by a sub-plantar injection of 100 µL of 1% α-carrageenan into the rat’s right hind paw. Three different doses of the ethanolic extract of TP were tested at different time periods (1, 3, and 5 hours). All doses of the TP ethanolic extract showed significant inhibition of α-carrageenan-induced rat paw edema in a dose-dependent manner in both early and late phases of edema formation. The size of the α-carrageen induced paw edema was significantly reduced one, three, and five hours after TP extract injection compared to the acute inflammation group. This inhibition was accompanied by high expression of interleukin 10 (IL-10) and low expression of monocyte chemoattractant protein 1 (MCP-1), IL-1β and tumor necrosis factor alpha (TNF-α). The results indicated that the ethanolic extracts of TP possess significant anti-inflammatory and potential pharmaceutical properties. https://www.bjbms.org/ojs/index.php/bjbms/article/view/9239Ethanolic plant extractacute inflammationα-carrageenanpaw edema |
| spellingShingle | Hamda A. Al-Naemi Reem Moath Alasmar Kaltham Al-Ghanim Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study Biomolecules & Biomedicine Ethanolic plant extract acute inflammation α-carrageenan paw edema |
| title | Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study |
| title_full | Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study |
| title_fullStr | Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study |
| title_full_unstemmed | Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study |
| title_short | Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study |
| title_sort | alcoholic extracts of teucrium polium exhibit remarkable anti inflammatory activity in vivo study |
| topic | Ethanolic plant extract acute inflammation α-carrageenan paw edema |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/9239 |
| work_keys_str_mv | AT hamdaaalnaemi alcoholicextractsofteucriumpoliumexhibitremarkableantiinflammatoryactivityinvivostudy AT reemmoathalasmar alcoholicextractsofteucriumpoliumexhibitremarkableantiinflammatoryactivityinvivostudy AT kalthamalghanim alcoholicextractsofteucriumpoliumexhibitremarkableantiinflammatoryactivityinvivostudy |