Inactivation of the Hippo tumor suppressor pathway promotes melanoma
Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma formation.
Bibliographic Details
| Main Authors: |
Marc A. Vittoria,
Nathan Kingston,
Kristyna Kotynkova,
Eric Xia,
Rui Hong,
Lee Huang,
Shayna McDonald,
Andrew Tilston-Lunel,
Revati Darp,
Joshua D. Campbell,
Deborah Lang,
Xiaowei Xu,
Craig J. Ceol,
Xaralabos Varelas,
Neil J. Ganem |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-31399-w
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