Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116
Nanotechnology-based targeting drug delivery systems have a considerable potential in medicine. Therefore, the present study aimed to designe, synthesise and characterize a nanodrug with beta lactoglobulin coating including oxali-palladium with and without folate and to compare their anti-cancer eff...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Kharazmi University
2021-10-01
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| Series: | یافتههای نوین در علوم زیستی |
| Subjects: | |
| Online Access: | http://nbr.khu.ac.ir/article-1-3424-en.html |
| _version_ | 1818956344952094720 |
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| author | Mahdieh Garshasbi Adeleh Divsalar |
| author_facet | Mahdieh Garshasbi Adeleh Divsalar |
| author_sort | Mahdieh Garshasbi |
| collection | DOAJ |
| description | Nanotechnology-based targeting drug delivery systems have a considerable potential in medicine. Therefore, the present study aimed to designe, synthesise and characterize a nanodrug with beta lactoglobulin coating including oxali-palladium with and without folate and to compare their anti-cancer effects. The physicochemical properties of nanocapsules were studied by Dynamic light scattering (DLS), atomic force microscopy (AFM) and scanning electron microscopy (SEM). Finally, the anticancer activities of nanodrugs were investigated against human colorectal cancer cell line of HCT116 by MTT and flowcytometry methods. The results of Dynamic light scattering (DLS), scanning electron microscopy (SEM) and atomic force microscopy (AFM) showed that the average size of nanocapsules with folate were less than 40 nm. Cytotoxicity results proved the dose- and time-dependent antiproliferation and anicancer activities of nanocapsules (with folate) against HCT116. Finally, it could be concluded that folate increase anticancer activity of nanodrugs and it might be considered as a new candidate in the design and synthesis of new drugs in cancer treatment. |
| first_indexed | 2024-12-20T10:52:28Z |
| format | Article |
| id | doaj.art-f742f290009145beaed3f1789d70e5f3 |
| institution | Directory Open Access Journal |
| issn | 2423-6330 2476-7115 |
| language | English |
| last_indexed | 2024-12-20T10:52:28Z |
| publishDate | 2021-10-01 |
| publisher | Kharazmi University |
| record_format | Article |
| series | یافتههای نوین در علوم زیستی |
| spelling | doaj.art-f742f290009145beaed3f1789d70e5f32022-12-21T19:43:13ZengKharazmi Universityیافتههای نوین در علوم زیستی2423-63302476-71152021-10-0183173182Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116Mahdieh Garshasbi0Adeleh Divsalar1 Isalmic Azad University Kharazmi University Nanotechnology-based targeting drug delivery systems have a considerable potential in medicine. Therefore, the present study aimed to designe, synthesise and characterize a nanodrug with beta lactoglobulin coating including oxali-palladium with and without folate and to compare their anti-cancer effects. The physicochemical properties of nanocapsules were studied by Dynamic light scattering (DLS), atomic force microscopy (AFM) and scanning electron microscopy (SEM). Finally, the anticancer activities of nanodrugs were investigated against human colorectal cancer cell line of HCT116 by MTT and flowcytometry methods. The results of Dynamic light scattering (DLS), scanning electron microscopy (SEM) and atomic force microscopy (AFM) showed that the average size of nanocapsules with folate were less than 40 nm. Cytotoxicity results proved the dose- and time-dependent antiproliferation and anicancer activities of nanocapsules (with folate) against HCT116. Finally, it could be concluded that folate increase anticancer activity of nanodrugs and it might be considered as a new candidate in the design and synthesis of new drugs in cancer treatment.http://nbr.khu.ac.ir/article-1-3424-en.htmlbeta lactoglobulin proteinhct116folatepectinnanodrug |
| spellingShingle | Mahdieh Garshasbi Adeleh Divsalar Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116 یافتههای نوین در علوم زیستی beta lactoglobulin protein hct116 folate pectin nanodrug |
| title | Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116 |
| title_full | Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116 |
| title_fullStr | Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116 |
| title_full_unstemmed | Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116 |
| title_short | Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116 |
| title_sort | investigation of presence of folate on physicochemical and anticancer properties of beta lactoglobulin nanocapsules against human colon cancer cell line of htc116 |
| topic | beta lactoglobulin protein hct116 folate pectin nanodrug |
| url | http://nbr.khu.ac.ir/article-1-3424-en.html |
| work_keys_str_mv | AT mahdiehgarshasbi investigationofpresenceoffolateonphysicochemicalandanticancerpropertiesofbetalactoglobulinnanocapsulesagainsthumancoloncancercelllineofhtc116 AT adelehdivsalar investigationofpresenceoffolateonphysicochemicalandanticancerpropertiesofbetalactoglobulinnanocapsulesagainsthumancoloncancercelllineofhtc116 |