Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy
Abstract Background The obesity and lipid metabolism were previously proposed to be related with the clinical outcomes of metastatic renal cell carcinoma (mRCC). We tried to investigate the relationship between preoperative cholesterol level (PCL) and survival outcomes in patients with mRCC. Methods...
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BMC
2017-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3322-5 |
| _version_ | 1828516952503484416 |
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| author | Hakmin Lee Yong June Kim Eu Chang Hwang Seok Ho Kang Sung-Hoo Hong Jinsoo Chung Tae Gyun Kwon Cheol Kwak Hyeon Hoe Kim Jong Jin Oh Sang Chul Lee Sung Kyu Hong Sang Eun Lee Seok-Soo Byun KOrean Renal Cell Carcinoma (KORCC) Group |
| author_facet | Hakmin Lee Yong June Kim Eu Chang Hwang Seok Ho Kang Sung-Hoo Hong Jinsoo Chung Tae Gyun Kwon Cheol Kwak Hyeon Hoe Kim Jong Jin Oh Sang Chul Lee Sung Kyu Hong Sang Eun Lee Seok-Soo Byun KOrean Renal Cell Carcinoma (KORCC) Group |
| author_sort | Hakmin Lee |
| collection | DOAJ |
| description | Abstract Background The obesity and lipid metabolism were previously proposed to be related with the clinical outcomes of metastatic renal cell carcinoma (mRCC). We tried to investigate the relationship between preoperative cholesterol level (PCL) and survival outcomes in patients with mRCC. Methods We analysed the data of 244 patients initially treated with cyto-reductive nephrectomy after being diagnosed with mRCC. Patients were stratified into two groups according to the PCL cut-off level of 170 mg/dL. The postoperative survival rates were compared using Kaplan-Meier analysis and the possible predictors of patients’ cancer-specific survival (CSS) and overall survival (OS) were tested using multivariate Cox-proportional hazard models. Results The low cholesterol group showed significantly worse postoperative CSS (p = 0.013) and OS (p = 0.009) than the high cholesterol group. On multivariate analysis, low PCL was revealed as an independent predictor of worse CSS (hazard ratio [HR], 2.162; 95% CI, 1.221–3.829; p = 0.008) and OS (HR, 2.013; 95% CI, 1.206–3.361; p = 0.007). Subsequent subgroup analysis showed that these results were maintained in the clear cell subgroup but not in the non-clear cell subgroup. Conclusion Decreased PCL was significantly correlated with worse survival outcomes in patients with mRCC treated with cytoreductive nephrectomy. The underlined mechanism is still uncharted and requires further investigation. |
| first_indexed | 2024-12-11T18:34:56Z |
| format | Article |
| id | doaj.art-f7486d3cd96a49728779675e6c7ffbda |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T18:34:56Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f7486d3cd96a49728779675e6c7ffbda2022-12-22T00:54:48ZengBMCBMC Cancer1471-24072017-05-011711710.1186/s12885-017-3322-5Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomyHakmin Lee0Yong June Kim1Eu Chang Hwang2Seok Ho Kang3Sung-Hoo Hong4Jinsoo Chung5Tae Gyun Kwon6Cheol Kwak7Hyeon Hoe Kim8Jong Jin Oh9Sang Chul Lee10Sung Kyu Hong11Sang Eun Lee12Seok-Soo Byun13KOrean Renal Cell Carcinoma (KORCC) GroupDepartment of Urology, Seoul National University Bundang HospitalDepartment of Urology, Chungbuk National University College of MedicineDepartment of Urology, Chonnam National University Hwasun HospitalDepartment of Urology, Korea University School of MedicineDepartment of Urology, College of Medicine, The Catholic University of KoreaDepartment of Urology, National Cancer CenterDepartment of Urology, Kyungpook National University College of MedicineDepartment of Urology, Seoul National University HospitalDepartment of Urology, Seoul National University HospitalDepartment of Urology, Seoul National University Bundang HospitalDepartment of Urology, Seoul National University Bundang HospitalDepartment of Urology, Seoul National University Bundang HospitalDepartment of Urology, Seoul National University Bundang HospitalDepartment of Urology, Seoul National University Bundang HospitalAbstract Background The obesity and lipid metabolism were previously proposed to be related with the clinical outcomes of metastatic renal cell carcinoma (mRCC). We tried to investigate the relationship between preoperative cholesterol level (PCL) and survival outcomes in patients with mRCC. Methods We analysed the data of 244 patients initially treated with cyto-reductive nephrectomy after being diagnosed with mRCC. Patients were stratified into two groups according to the PCL cut-off level of 170 mg/dL. The postoperative survival rates were compared using Kaplan-Meier analysis and the possible predictors of patients’ cancer-specific survival (CSS) and overall survival (OS) were tested using multivariate Cox-proportional hazard models. Results The low cholesterol group showed significantly worse postoperative CSS (p = 0.013) and OS (p = 0.009) than the high cholesterol group. On multivariate analysis, low PCL was revealed as an independent predictor of worse CSS (hazard ratio [HR], 2.162; 95% CI, 1.221–3.829; p = 0.008) and OS (HR, 2.013; 95% CI, 1.206–3.361; p = 0.007). Subsequent subgroup analysis showed that these results were maintained in the clear cell subgroup but not in the non-clear cell subgroup. Conclusion Decreased PCL was significantly correlated with worse survival outcomes in patients with mRCC treated with cytoreductive nephrectomy. The underlined mechanism is still uncharted and requires further investigation.http://link.springer.com/article/10.1186/s12885-017-3322-5Renal cell carcinomaCholesterolSurvivalMetastasisHypercholesterolemia |
| spellingShingle | Hakmin Lee Yong June Kim Eu Chang Hwang Seok Ho Kang Sung-Hoo Hong Jinsoo Chung Tae Gyun Kwon Cheol Kwak Hyeon Hoe Kim Jong Jin Oh Sang Chul Lee Sung Kyu Hong Sang Eun Lee Seok-Soo Byun KOrean Renal Cell Carcinoma (KORCC) Group Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy BMC Cancer Renal cell carcinoma Cholesterol Survival Metastasis Hypercholesterolemia |
| title | Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy |
| title_full | Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy |
| title_fullStr | Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy |
| title_full_unstemmed | Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy |
| title_short | Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy |
| title_sort | preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto reductive nephrectomy |
| topic | Renal cell carcinoma Cholesterol Survival Metastasis Hypercholesterolemia |
| url | http://link.springer.com/article/10.1186/s12885-017-3322-5 |
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