Wnt Site Signaling Inhibitor Secreted Frizzled‐Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction–Induced Endothelial‐to‐Mesenchymal Transition

Wnt Site Signaling Inhibitor Secreted Frizzled‐Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction–Induced Endothelial‐to‐Mesenchymal Transition

Background The onset and mechanisms of endothelial‐to‐mesenchymal transition (EndMT) in mitral valve (MV) leaflets following myocardial infarction (MI) are unknown, yet these events are closely linked to stiffening of leaflets and development of ischemic mitral regurgitation. We investigated whether...

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Bibliographic Details
Main Authors: Zahra Alvandi, Yasufumi Nagata, Livia Silva Araúujo Passos, Ali Hashemi Gheinani, J. Luis Guerrero, Jill Wylie‐Sears, Dayana Carolina Romero, Brittan A. Morris, Suzanne M. Sullivan, Koushiar M. Yaghoubian, Amirhossein Alvandi, Rosalyn M. Adam, Elena Aikawa, Robert A. Levine, Joyce Bischoff
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelial‐to‐mesenchymal transition
ischemic mitral regurgitation
mitral valve
myocardial infarction
Wnt signaling
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.023695

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.023695

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