Correlation between bone mineral density and sarcopenia in US adults: a population-based study
Abstract Introduction In the aging process of the body, in addition to changes in fat and muscle content, there is also bone loss, implying the possibility of a strong muscle–bone–lipid link. In this study, we initially investigated the relationship between lumbar BMD and low muscle mass and the rel...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-023-04034-7 |
| _version_ | 1827633724068462592 |
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| author | Lulu Cheng Siyu Wang |
| author_facet | Lulu Cheng Siyu Wang |
| author_sort | Lulu Cheng |
| collection | DOAJ |
| description | Abstract Introduction In the aging process of the body, in addition to changes in fat and muscle content, there is also bone loss, implying the possibility of a strong muscle–bone–lipid link. In this study, we initially investigated the relationship between lumbar BMD and low muscle mass and the relationship between “muscle–bone–lipid.” Methods The datasets from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 were used in a cross-sectional investigation. BMD and appendicular skeletal muscle (ASM) were measured by dual-energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by body mass index (BMI) as a marker of sarcopenia. Weighted multivariate regression and logistic regression analysis were used to explore the independent relationship between lumbar BMD and sarcopenia. Fitted smoothing curves and threshold effect analysis were used to describe the nonlinear relationship. Result In 8386 participants with ages 20–59 years, there was a negative association between lumbar BMD and sarcopenia. In the fully adjusted model, the risk of developing sarcopenia decreased by 93% for each 1-unit increase in lumbar BMD (OR = 0.07, 95%CI 0.03–0.20). The risk of sarcopenia was 58% lower in participants in the highest quartile of lumbar BMD than in those in the lowest quartile (OR = 0.42, 95%CI 0.27–0.64). This negative association was more pronounced in the population of women with BMI ≥ 25. Conclusion Our findings suggest that lumbar BMD is negatively associated with sarcopenia in US adults. The dynamic balance between “muscle–bone–lipid” is likely to be related to the pathogenesis of bone loss. |
| first_indexed | 2024-03-09T15:03:31Z |
| format | Article |
| id | doaj.art-f74bd8ecdda647828dc5cc528f7b4c4b |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-09T15:03:31Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-f74bd8ecdda647828dc5cc528f7b4c4b2023-11-26T13:48:38ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-08-011811810.1186/s13018-023-04034-7Correlation between bone mineral density and sarcopenia in US adults: a population-based studyLulu Cheng0Siyu Wang1College of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese MedicineGraduate School, Wuhan Sports UniversityAbstract Introduction In the aging process of the body, in addition to changes in fat and muscle content, there is also bone loss, implying the possibility of a strong muscle–bone–lipid link. In this study, we initially investigated the relationship between lumbar BMD and low muscle mass and the relationship between “muscle–bone–lipid.” Methods The datasets from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 were used in a cross-sectional investigation. BMD and appendicular skeletal muscle (ASM) were measured by dual-energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by body mass index (BMI) as a marker of sarcopenia. Weighted multivariate regression and logistic regression analysis were used to explore the independent relationship between lumbar BMD and sarcopenia. Fitted smoothing curves and threshold effect analysis were used to describe the nonlinear relationship. Result In 8386 participants with ages 20–59 years, there was a negative association between lumbar BMD and sarcopenia. In the fully adjusted model, the risk of developing sarcopenia decreased by 93% for each 1-unit increase in lumbar BMD (OR = 0.07, 95%CI 0.03–0.20). The risk of sarcopenia was 58% lower in participants in the highest quartile of lumbar BMD than in those in the lowest quartile (OR = 0.42, 95%CI 0.27–0.64). This negative association was more pronounced in the population of women with BMI ≥ 25. Conclusion Our findings suggest that lumbar BMD is negatively associated with sarcopenia in US adults. The dynamic balance between “muscle–bone–lipid” is likely to be related to the pathogenesis of bone loss.https://doi.org/10.1186/s13018-023-04034-7Lumbar bone mineral densityOsteoporosisSarcopeniaMuscle–bone–lipidNHANES |
| spellingShingle | Lulu Cheng Siyu Wang Correlation between bone mineral density and sarcopenia in US adults: a population-based study Journal of Orthopaedic Surgery and Research Lumbar bone mineral density Osteoporosis Sarcopenia Muscle–bone–lipid NHANES |
| title | Correlation between bone mineral density and sarcopenia in US adults: a population-based study |
| title_full | Correlation between bone mineral density and sarcopenia in US adults: a population-based study |
| title_fullStr | Correlation between bone mineral density and sarcopenia in US adults: a population-based study |
| title_full_unstemmed | Correlation between bone mineral density and sarcopenia in US adults: a population-based study |
| title_short | Correlation between bone mineral density and sarcopenia in US adults: a population-based study |
| title_sort | correlation between bone mineral density and sarcopenia in us adults a population based study |
| topic | Lumbar bone mineral density Osteoporosis Sarcopenia Muscle–bone–lipid NHANES |
| url | https://doi.org/10.1186/s13018-023-04034-7 |
| work_keys_str_mv | AT lulucheng correlationbetweenbonemineraldensityandsarcopeniainusadultsapopulationbasedstudy AT siyuwang correlationbetweenbonemineraldensityandsarcopeniainusadultsapopulationbasedstudy |