Direct Binding of Cisplatin to p22phox, an Endoplasmic Reticulum (ER) Membrane Protein, Contributes to Cisplatin Resistance in Oral Squamous Cell Carcinoma (OSCC) Cells

Direct Binding of Cisplatin to p22phox, an Endoplasmic Reticulum (ER) Membrane Protein, Contributes to Cisplatin Resistance in Oral Squamous Cell Carcinoma (OSCC) Cells

Prolonged treatment with cisplatin (CDDP) frequently develops chemoresistance. We have previously shown that p22phox, an endoplasmic reticulum (ER) membrane protein, confers CDDP resistance by blocking CDDP nuclear entry in oral squamous cell carcinoma (OSCC) cells; however, the underlying mechanism...

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Bibliographic Details
Main Authors: Chih-Chang Hung, Fu-An Li, Shih-Shin Liang, Ling-Feng Wang, I-Ling Lin, Chien-Chih Chiu, Chiu-Hsien Lee, Jeff Yi-Fu Chen
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
p22phox
cisplatin
drug-protein interaction
chemoresistance
oral squamous cell carcinoma (OSCC)
Online Access:https://www.mdpi.com/1420-3049/25/17/3815

Internet

https://www.mdpi.com/1420-3049/25/17/3815

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