Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia

Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia

Abstract The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes one of the rate‐limiting steps in de novo pyrimidine biosynthesis, a pathway that provides essential metabolic precursors for nucleic acids, glycoproteins, and phospholipids. DHODH inhibitors (DHODHi) are clinically use...

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Bibliographic Details
Main Authors: Joan So, Alexander C Lewis, Lorey K Smith, Kym Stanley, Rheana Franich, David Yoannidis, Lizzy Pijpers, Pilar Dominguez, Simon J Hogg, Stephin J Vervoort, Fiona C Brown, Ricky W Johnstone, Gabrielle McDonald, Danielle B Ulanet, Josh Murtie, Emily Gruber, Lev M Kats
Format: Article
Language:English
Published: Springer Nature 2022-05-01
Series:EMBO Molecular Medicine
Subjects:
acute myeloid leukemia
DHODH
leukemic stem cells
protein translation
Online Access:https://doi.org/10.15252/emmm.202115203

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